Endosulfan induced cardiac arrest treated with intravenous lipid emulsion

Endosulfan induced cardiac arrest treated with intravenous lipid emulsion


  • Sema Avcı Kars Harakani State Hospital
  • Ayşe Başaran Iğdır State Hospital
  • Selim Genç
  • Seda Özkan
  • Engin Deniz Arslan


Endosulfan toxicity, Intravenous Lipid Emulsion, Cardiac Arrest, Emergency Medicine


Objective: Endosulfan is an organochlorine pesticide with high lipophilic features that makes it a well-absorbed agent and penetrates easily to the site of action. Endosulfan toxicities may result in disastrous complications and have high rates of mortality. Several case reports and some researchs discuss the evidence supporting intravenous lipid emulsion (ILE) therapy as a rescue therapy in lipophilic agents’ toxicity. Case report: A 33-years-old healthy woman with  a history of endosulfan ingestion of uncertain quantity in a suicide attempt six hours ago was admitted to our emergency department. Cardiac arrest ensued after one hour of admission. Cardiopulmonary resuscitation was initiated in accordance with advanced cardiac life support (ACLS) algorithm for asystole. During resuscitation, 2 mL/kg bolus of 20% intravenous lipid emulsion (ILE) was administered for three times at five-minute intervals in addition to ACLS guidance. Spontaneous circulation returned after twenty minutes of resuscitation. No additional antidotal or vasopressor therapies were required during the hospital course of the patient. To our knowledge, this is the first reported case with responded use of ILE treatment for endosulfan toxicity. Conclusion: This case report indicates that ILE treatment should be considered for life-threatening endosulfan intoxications.

Author Biographies

Sema Avcı, Kars Harakani State Hospital

Emergency Department

Ayşe Başaran, Iğdır State Hospital

Emergency Medicine

Selim Genç

Emergency Medicine

Seda Özkan

Emergency Medicine

Engin Deniz Arslan

Emergency Medicine







How to Cite

Endosulfan induced cardiac arrest treated with intravenous lipid emulsion. Acta Biomed [Internet]. 2019 Jan. 15 [cited 2024 Jun. 18];89(4):573-5. Available from: https://mattioli1885journals.com/index.php/actabiomedica/article/view/6582

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