Peculiarities of autoimmune polyglandular syndromes in children and adolescents

Giuseppina Zirilli; Simona Santucci; Chiara Cuzzupè; Domenico Corica; Elda Pitrolo; Giuseppina Salzano

doi:10.23750/abm.v88i3.5898

Peculiarities of autoimmune polyglandular syndromes in children and adolescents

Authors

Giuseppina Zirilli Department of Human Pathology of Adulthood and Childhood, University of Messina, Messina, Italy
Simona Santucci Department of Human Pathology of Adulthood and Childhood, University of Messina, Messina, Italy
Chiara Cuzzupè Department of Human Pathology of Adulthood and Childhood, University of Messina, Messina, Italy
Domenico Corica Department of Human Pathology of Adulthood and Childhood, University of Messina, Messina, Italy
Elda Pitrolo Department of Human Pathology of Adulthood and Childhood, University of Messina, Messina, Italy
Giuseppina Salzano Department of Human Pathology of Adulthood and Childhood, University of Messina, Messina, Italy

Keywords:

Associations of autoimmune disorders, epidemiology, immunodeficiency, phenotypical expression

Abstract

Background: no reviews have specifically addressed , to now, whether autoimmune polyglandular syndromes (APSs) may have a peculiar epidemiology and phenotypical expression in pediatric age

Objectives: to review the most recent literature data about the specific epidemiological and clinical peculiarities of APSs in childhood and adolescence

Design: the main features of the different APSs in pediatric age were compared among them.

Conclusions: 1) Among the different APSs, the one that is most typical of pediatric age is APS-1; 2) APS-1 is not characterized only by the classical triad (chronic moniliasis-hyposurrenalism-hypoparathyroidism) and its clinical spectrum is enlarging over time; 3)APS-2 may have a different epidemiological and clinical expression according to two different nosological classifications.

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Published

23-10-2017

Issue

Vol. 88 No. 3 (2017): Acta BioMedica 3-2017

Section

REVIEWS

License

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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How to Cite

Zirilli G, Santucci S, Cuzzupè C, Corica D, Pitrolo E, Salzano G. Peculiarities of autoimmune polyglandular syndromes in children and adolescents. Acta Biomed. 2017;88(3):271-275. doi:10.23750/abm.v88i3.5898

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