The Schmidt Syndrome

The Schmidt Syndrome


  • Carmine Siniscalchi Parma University Hospital
  • Valentina Moretti
  • Simona Cataldo
  • Anna Rocci
  • Manuela Basaglia
  • Maria Ilaria Tassoni
  • Roberto Quintavalla


autoimmune polyendocrine syndrome, autoimmune Addison's disease, Schmidt syndrome


Addison’s disease (AD) is a rare endocrine condition related to adrenal insufficiency. Autoimmune adrenalitis is commonly associated with autoimmune diseases. Autoimmune Addison’s Disease (AAD) describes Autoimmune Polyendocrine Syndrome (APS) in 60% of patients with an important immunitary pathogenesis imprinting. We describes a case of Autoimmune Polyendocrine Syndrome charachterize by adrenal insufficiency and thyroid disease (Schmidt Syndrome). In this case report, Addison’s disease had a slow onset in absence of the typical weight loss. In our considerations this is due to the concomitant hypothyroidism that masked some typical signs and also limited acute presentation. 




How to Cite

Siniscalchi C, Moretti V, Cataldo S, Rocci A, Basaglia M, Tassoni MI, et al. The Schmidt Syndrome. Acta Biomed [Internet]. 2018 Jan. 16 [cited 2024 Jul. 23];88(4):499-501. Available from: