Prognostic value of endometrial thickness in predicting pregnancy onset in IVF cycles: Insights from the “Ansagan Sabi” state program in Kazakhstan
Keywords:
Endometrial thickness, IVF, pregnancy onset, prognostic value, "Ansagan Sabi" program, KazakhstanAbstract
Background: The introduction of the "Ansagan Sabi" program has expanded access to infertility treatment to patients in Kazakhstan. Endometrial thickness is a crucial factor in determining endometrial receptivity and, consequently, the success of in vitro fertilization (IVF) procedures. Our study seeks to assess the prognostic value of endometrial thickness as a predictor of pregnancy onset in patients undergoing fresh IVF cycles as part of the implementation of the “Ansagan Sabi” state program.
Methods: A retrospective analysis was conducted on 279 women who underwent IVF fresh cycle procedures and were recruited under the "Ansagan Sabi" program. Strict selection criteria were applied during the outpatient stage. Demographic and clinical data, including endometrial thickness, were collected for analysis.
Results: The analysis revealed that endometrial thickness significantly influenced the likelihood of pregnancy onset, as assessed by logistic regression analysis. Patients with endometrial thickness below 5 mm (Group 1) and between 5 and 7 mm (Group 2) exhibited decreased odds of pregnancy onset compared to those with thicknesses equal to or greater than 7 mm (Group 3).
Conclusion: Optimal endometrial thickness, indicated by thicknesses equal to or greater than 7 mm, was associated with improved pregnancy outcomes. The study findings have implications for patient management strategies within the "Ansagan Sabi" program and underscore the importance of optimizing endometrial conditions to enhance IVF success rates. Further research incorporating larger sample sizes and multicenter studies is warranted to validate the findings and explore additional prognostic factors.
References
Ferraretti AP, La Marca A, Fauser BCJM, Tarlatzis B, Nargund G GL. ESHRE consensus on the definition of ’poor response to ovarian stimulation for in vitro fertilization: The Bologna criteria. Hum Reprod. 2011;26(7):1616–24. https://doi.org/10.1093/humrep/der092
Ministtry of Health of the Republic of Kazakhstan. Order #272: The approval of rules and conditions for conducting assisted reproductive methods and technologies. Astana; 2020. Available from: https://adilet.zan.kz/rus/docs/V2100023144
Social Health Insurance Fund. Under the State “Ansagan Sabi” program, funded by the Compulsory Social Health Insurance Fund, more than 5,000 newborns were born. 2023. Available from: https://fms.kz/kz/press-center/press-relizy/94076/
Achache H, Revel A. Endometrial receptivity markers, the journey to successful embryo implantation. Hum Reprod Update. 2006;12(6):731–46. https://doi.org/10.1093/humupd/dml004
Zhang T, Li Z, Ren X, Huang B, Zhu G, Yang W, et al. Endometrial thickness as a predictor of the reproductive outcomes in fresh and frozen embryo transfer cycles: A retrospective cohort study of 1512 IVF cycles with morphologically good-quality blastocyst. Medicine (Baltimore). 2018;97(4). https://doi.org/10.5152/eurjther.2021.20102
Yuan X, Saravelos SH, Wang Q, Xu Y, Li T-C, Zhou C. Endometrial thickness as a predictor of pregnancy outcomes in 10787 fresh IVF–ICSI cycles. Reprod Biomed Online. 2016;33(2):197–205. https://doi.org/10.1016/j.rbmo.2016.05.002
Al-Ghamdi A, Coskun S, Al-Hassan S, Al-Rejjal R, Awartani K. The correlation between endometrial thickness and outcome of in vitro fertilization and embryo transfer (IVF-ET) outcome. Reprod Biol Endocrinol. 2008;6:1–5. https://doi.org/10.1186/1477-7827-6-37
Kasius A, Smit JG, Torrance HL, Eijkemans MJC, Mol BW, Opmeer BC, et al. Endometrial thickness and pregnancy rates after IVF: A systematic review and meta-analysis. Hum Reprod Update. 2014;20(4):530–41. https://doi.org/10.1093/humupd/dmu011
Moshkalova G, Karibayeva I, Kurmanova A, Mamedalieva N, Aimbetova A, Terlikbayeva A, et al. Endometrial thickness and live birth rates after IVF: a systematic review. Acta Biomed. 2023;94(3). https://doi.org/10.23750/abm.v94i3.14437
Zargar M, Razmkhah N, Nikbakht R. Evaluating the factors associated with pregnancy loss in pregnant women undergoing assisted reproductive techniques. Middle East Fertil Soc J [I. 2018;23(4):342–5. Available from: https://doi.org/10.1016/j.mefs.2018.04.009
IBM Corp. IBM SPSS Statistics for Windows (Version 21.0). USA, Armonk, NY; 2012.
Akimat of Birzhan sal district. More than 4,500 babies have been born during the “Ansagan Sabi” program, 2023. Available from: https://www.gov.kz/memleket/entities/aqmola-birzhan-sal/press/article/details/130720?lang=kk
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Copyright (c) 2024 Gaukhar Moshkalova, Almagul Kurmanova , Nagima Mamedalieva, Aliya Aimbetova , Damilya Salimbayeva , Gaukhar Kurmanova , Gaini Anartayeva , Radha Aripova , Indira Karibayeva
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