Combination treatment of dupilumab with bortezomib in a patient with IgG kappa gammopathy of renal significance, uremic pruritus and chronic lichenoid dermatitis

Combination treatment of dupilumab with bortezomib in a patient with IgG kappa gammopathy of renal significance, uremic pruritus and chronic lichenoid dermatitis

Authors

  • Paolino Giovanni IRCCS San Raffaele Hospital
  • Matteo Riccardo Di Nicola IRCCS San Raffaele Hospital
  • Magda Marcatti IRCCS San Raffaele Hospital
  • Nathalie Rizzo IRCCS San Raffaele Hospital
  • Vittoria Bianchi IRCCS San Raffaele Hospital
  • Valeria Ferla IRCCS San Raffaele Hospital
  • Santo Raffaele Mercuri IRCCS San Raffaele Hospital

Keywords:

chronic itchy skin, combined treatment, Dupixent, itch, monoclonal antibody

Abstract

Chronic pruritus (CP) is one of the most frequent symptoms among dermatological conditions, capable of reducing the quality of life (QoL). CP may be induced by atopic dermatitis or other dermatological and/or non-dermatological conditions. In this article, we report the case of a patient affected by generalized CP, characterised by multiple papulo-nodular and escoriatic lesions, developed after the onset of an immunoglobulin G (IgG) kappa monoclonal gammopathy of renal significance (MGRS), associated with renal insufficiency. Therefore, a combined treatment with dupilumab for CP and bortezomib for the hematologic malignancy was administered to the patient. The present case report highlights the efficacy of dupilumab for the treatment of CP. Moreover, no relevant side effects were recorded during the treatment in combination with other systemic biological drugs for other systemic pathologies.

References

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Published

17-10-2023

Issue

Section

CASE REPORTS

How to Cite

1.
Giovanni P, Di Nicola MR, Marcatti M, Bianchi V, Ferla V, Mercuri SR. Combination treatment of dupilumab with bortezomib in a patient with IgG kappa gammopathy of renal significance, uremic pruritus and chronic lichenoid dermatitis. Acta Biomed [Internet]. 2023 Oct. 17 [cited 2024 Jul. 15];94(5):e2023241. Available from: https://mattioli1885journals.com/index.php/actabiomedica/article/view/14279