Pediatric obesity: a mini-review for pediatrician

Pediatric obesity: a mini-review for pediatrician

Authors

Keywords:

children, adolescents, type 2 diabetes, obesity, insulin resistance, metabolic syndrome, Polysaccharide Complex

Abstract

Obesity is a multifactorial disease, and its prevalence in children has been increased over the last 30 years in Italy and many other European Countries. Obesity significantly impacts the quality of life of affected patients and health care systems. Obesity is related to several clinical comorbidities, especially metabolic syndrome and diabetes. The standard of care in this patient is still considered lifestyle changes and a healthy diet with regular physical activity to prevent associated metabolic complications (impaired glucose tolerance and type 2 diabetes) and reduce cardiovascular risk.Therefore, pediatricians should recognize potential risk factors (sedentary lifestyle, sugar, and fats-rich diet, genetic syndromes) and early signs of overweight and obesity to promptly address the child to a pediatric endocrinologist and a specialized reference Center.

References

Vasileva LV, Marchev AS, Georgiev MI. Causes and solutions to "globesity": The new fa(s)t alarming global epidemic. Food Chem Toxicol. 2018;121:173-93.

NCD Risk Factor Collaboration (NCD-RisC). Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128·9 million children, adolescents, and adults. Lancet. 2017 ;390(10113):2627-42.

Valerio G, Licenziati MR, Manco M, et al. Health consequences of obesity in children and adolescents. Minerva Pediatr. 2014;66(5):381-414.

Skinner AC, Skelton JA. Prevalence and trends in obesity and severe obesity among children in the United States, 1999-2012. JAMA Pediatr. 2014;168(6):561-6.

Childhood Obesity Surveillance Initiative (COSI) Factsheet. Highlights 2015-17; 2018. www.euro.who.int

Indagine nazionale 2019: i dati nazionali - EpiCentro – ISS; www.epicentro.iss.it

OKkio alla Salute: i dati nazionali. https://www.epicentro.iss.it/okkioallasalute/indagine-2019-dati

Consensus nazionale su diagnosi, trattamento e prevenzione dell'Obesità del bambino e dell'adolescente. SIP-SIEDP (2017) http://www.siedp.it/files/Doc.ConsensusObesita__2017.pdf

Cole TJ, Lobstein T. Extended international (IOTF) body mass index cut-offs for thinness, overweight, and obesity. Pediatr Obes. 2012;7(4):284-94.

Cacciari E, Milani S, Balsamo A, et al. Italian cross-sectional growth charts for height, weight and BMI (2 to 20 yr). J Endocrinol Invest. 2006;29(7):581-93.

Stunkard AJ. The Salmon lecture. Some perspectives on human obesity: its causes. Bull N Y Acad Med. 1988;64(8):902-23.

Pi-Sunyer FX. The obesity epidemic: pathophysiology and consequences of obesity. Obes Res. 2002;10 Suppl 2:97S-104S.

Mameli C, Mazzantini S, Zuccotti GV. Nutrition in the First 1000 Days: The Origin of Childhood Obesity. Int J Environ Res Public Health. 2016;13(9):838.

Rolland-Cachera MF, Deheeger M, Maillot M, et al. Early adiposity rebound: causes and consequences for obesity in children and adults. Int J Obes (Lond). 2006;30 Suppl 4:S11-7.

Cardel MI, Atkinson MA, Taveras EM, et al. Obesity Treatment Among Adolescents: A Review of Current Evidence and Future Directions. JAMA Pediatr. 2020;174(6):609-17.

Spitzer JA, Kovach AG, Rosell S, et al. Influence of endotoxin on adipose tissue metabolism. Adv Exp Med Biol. 1972;33(0):337-44.

Hotamisligil GS, Shargill NS, Spiegelman BM. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science. 1993 Jan 1;259(5091):87-91.

Singer K, Lumeng CN. The initiation of metabolic inflammation in childhood obesity. J Clin Invest. 2017 Jan 3;127(1):65-73.

Angi A, Chiarelli F. Obesity and Diabetes: A Sword of Damocles for Future Generations. Biomedicines. 2020 Nov 6;8(11):478.

Matsuda M, DeFronzo RA. Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. Diabetes Care. 1999;22(9):1462-70.

Matthews DR, Hosker JP, Rudenski AS, et al. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28(7):412-9.

Anderson EL, Howe LD, Jones HE, et al. The Prevalence of Non-Alcoholic Fatty Liver Disease in Children and Adolescents: A Systematic Review and Meta-Analysis. PLoS One. 2015;10(10):e0140908.

Flynn J. The changing face of pediatric hypertension in the era of the childhood obesity epidemic. Pediatr Nephrol. 2013 Jul;28(7):1059-66.

Hou Y, Wang M, Yang L, et al. Weight status change from childhood to early adulthood and the risk of adult hypertension. J Hypertens. 2019;37(6):1239-43.

Chanoine JP, Hampl S, Jensen C, et al. Effect of orlistat on weight and body composition in obese adolescents: a randomized controlled trial. JAMA. 2005;293(23):2873-83.

Umano GR, Pistone C, Tondina E, et al. Pediatric Obesity and the Immune System. Front Pediatr. 2019 Nov 22;7:487.

Kelly AS, Auerbach P, Barrientos-Perez M, et al; NN8022-4180 Trial Investigators. A Randomized, Controlled Trial of Liraglutide for Adolescents with Obesity. N Engl J Med. 2020;382(22):2117-28.

Stagi S, Ricci F, Bianconi M, et al. Retrospective Evaluation of Metformin and/or Metformin Plus a New Polysaccharide Complex in Treating Severe Hyperinsulinism and Insulin Resistance in Obese Children and Adolescents with Metabolic Syndrome. Nutrients. 2017;9(5):524.

Fornari E, Morandi A, Piona C, et al. Policaptil Gel Retard Intake Reduces Postprandial Triglycerides, Ghrelin and Appetite in Obese Children: A Clinical Trial. Nutrients. 2020 Jan;12(1):214.

Greco CM, Garetto S, Montellier E, et al. A non-pharmacological therapeutic approach in the gut triggers distal metabolic rewiring capable of ameliorating diet-induced dysfunctions encompassed by metabolic syndrome. Sci Rep. 2020;10(1):12915.

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Published

06-06-2022

How to Cite

1.
Brambilla I, Bellanca E, Pistone C, et al. Pediatric obesity: a mini-review for pediatrician. Acta Biomed. 2022;93(S3):e2022197. doi:10.23750/abm.v93iS3.13078