The efficacy of brief strategic therapy in treating obsessive-compulsive disorder: a case series
Brief strategic therapy and OCD
Keywords:
Brief strategic therapy, Obsessive-compulsive disorder, Treatment, Psychotherapy, RemissionAbstract
Background and aim: International guidelines indicate pharmacological therapy and cognitive-behavioral therapy (CBT) as gold standard treatments for obsessive-compulsive disorder (OCD). However, up to 40% patients do not fully respond to CBT, thus manifesting persistent symptomatology. Empirical research reported brief strategic therapy (BST) as a potential treatment for OCD. The aim of the present study is to evaluate the efficacy of BST in treating OCD and to identify the clinical characteristics associated to response.
Methods: BST protocol was administered to patients with OCD. During a 24-weeks observational phase, the following scales have been administered at the baseline and every 4 weeks: Yale Brown Obsessive-Compulsive scale (Y-BOCS), Clinical Global Impression, Global Assessment of Functioning, Quality of Life Index, Medical Outcomes Study Short Form 12-item, Clinical Outcomes in Routine Evaluation-Outcome Measure, Generalized Anxiety Disorder Scale, Patient Health Questionnaire - 9 and Somatic Symptom Scale-8.
Results: eight patients completed the treatment and a subgroup of five patients obtained clinical remission, defined as Y-BOCS total score < 25. The repeated measures ANOVA performed showed a significant decreased of the Y-BOCS total scores (p<.001). Comparisons between the two subgroups (remitters vs. non-remitters) highlighted some potential baseline characteristics associated with remission: i.e., higher mean level of anxiety, quality of life, physical health, and lower mean level of somatic symptoms and lower prevalence of personality disorders comorbidity.
Conclusions: BST could be a useful therapeutic strategy in treating OCD patients. Further studies with larger samples and with long-term follow-up are needed to assess the post-treatment maintenance of clinical effects.
References
American Psychiatric Association. Diagnostic and statistical manual of mental disorders (5th edition). Washington, DC: American Psychiatric Association. 2013.
Ruscio AM, Stein DJ, Chiu WT, Kessler RC. The epidemiology of obsessive-compulsive disorder in the National Comorbidity Survey Replication. Mol Psychiatry 2010; 15(1): 53-63.
Albert U, Aguglia A, Chiarle A, Bogetto F, Maina G. Metabolic syndrome and obsessive-compulsive disorder: A naturalistic Italian study. Gen Hosp Psychiatry 2013; 35: 154-9.
Aguglia A, Signorelli MS, Albert U, Maina G. The impact of general medical conditions in obsessive-compulsive disorder. Psychiatry Investig 2018; 15: 246-53.
Tonna M, Amerio A, Ottoni R, et al. The clinical meaning of obsessive-compulsive symptoms in bipolar disorder and schizophrenia. Aust N Z J Psychiatry 2015; 49(6): 578-9.
Amerio A, Tonna M, Odone A, Stubbs B, Ghaemi SN. Corse of illness in comorbid bipolar disorder and obsessive-compulsive disorder patients. Asian J Psychiatr 2016; 20: 12-4.
Benatti B, Dell’Osso B, Shen H, et al. Prevalence and correlates of current suicide risk in an international sample of OCD adults: A report from the International College of Obsessive-Compulsive Spectrum Disorders (ICOCS) network and Obsessive Compulsive and Related Disorders Network (OCRN) of the European College of Neuropsychopharmacology. J Psychiatr Res 2021; 140: 357-63.
Baertschi M, Costanza A, Canuto A, Weber K. The dimensionality of suicidal ideation and its clinical implications. Int J Methods Psychiatr Res 2019; 28(1): e1755.
American Psychiatric Association. Guideline Watch (March 2013): Practice Guideline for the treatment of patients with obsessive-compulsive disorder. Arlington, VA: American Psychiatric Association 2013.
Nezgovorova V, Reid J, Fineberg NA, Hollander E. Optimizing first line treatments for adults with OCD. Compr Psychiatry 2022; 115: 152305.
Sugarman MA, Kirsch I, Huppert JD. Obsessive-compulsive disorder has a reduced placebo (and antidepressant) response compared to other anxiety disorders: A meta-analysis. J Affect Disord 2017; 218: 217-26.
Cuijpers P, Sijbrandij M, Koole SL, Andersson G, Beekman AT, Reynolds 3rd C. The efficacy of psychotherapy and pharmacotherapy in treating depressive and anxiety disorders: a meta‐analysis of direct comparisons. World Psychiatry 2013; 12: 137-48.
Albert U, Di Salvo G, Solia F, Rosso G, Maina G. Combining Drug and Psychological Treatments for Obsessive-Compulsive Disorder: What is the Evidence, When and for Whom. Curr Med Chem 2018; 25: 5632-46.
Storch EA, Björgvinsson T, Riemann B, Lewin AB, Morales MJ, Murphy TK. Factors associated with poor response in cognitive-behavioral therapy for pediatric obsessive-compulsive disorder. Bull Menninger Clin 2010; 74: 167-85.
Hezel DM, Simpson HB. Exposure and response prevention for obsessive-compulsive disorder: A review and new directions. Indian J Psychiatry 2019; 61: S85-S92.
Kulz AK, Landmann S, Schmidt-Ott M, Zurowski B, Wahl-Kordon A, Voderholzer U. Long-Term Follow-up of Cognitive-Behavioral Therapy for Obsessive-Compulsive Disorder: Symptom Severity and the Role of Exposure 8-10 Years After Inpatient Treatment. J Cogn Psychother 2020; 34(3): 261-71.
Skapinakis P, Caldwell DM, Hollingworth W, et al. Pharmacological and psychotherapeutic interventions for management of obsessive-compulsive disorder in adults: a systematic review and network meta-analysis. Lancet Psychiatry 2016; 3: 730-9.
Hirschtritt ME, Bloch MH, Mathews CA. Obsessive-compulsive disorder: Advances in diagnosis and treatment. JAMA 2017; 317(13): 1358-67.
Torres AR, Prince MJ, Bebbington PE, et al. Treatment seeking by individuals with obsessive- compulsive disorder from the british psychiatric morbidity survey of 2000. Psychiatr Serv 2007; 58(7): 977-82.
Albert U, Barbaro F, Aguglia A, Maina G, Bogetto F. Combined treatments in obsessive-compulsive disorder: current knowledge and future prospects. Riv Psichiatr 2012a; 47(4): 255-68.
Del Casale A, Sorice S, Padovano A, et al. Psychopharmacological Treatment of Obsessive-Compulsive Disorder (OCD). Curr Neuropharmacol 2019; 17: 710-36.
Abramowitz JS, Taylor S, McKay D. Obsessive-compulsive disorder. Lancet 2009; 374: 491-9.
Pietrabissa G, Manzoni GM, Gibson P, Boardman D, Gori A, Castelnuovo G. Brief strategic therapy for obsessive–compulsive disorder: a clinical and research protocol of a one-group observational study. BMJ Open 2016; 6: e009118.
Portelli C. Brief strategic interventions for obsessive compulsive disorders: acquiring the maximum with the minimum in the first session. Brief Strat Syst Ther Eur Rev 2005; 2: 56-70.
Nardone G, Portelli C. Cambiare per conoscere: L'evoluzione della terapia breve strategica, TEA - Tascabili degli Editori Associati, Milano, 2015.
Albert U, Aguglia A, Bogetto F, et al. Effectiveness and predictors of response to cognitive-behavioural therapy as an augmentation to pharmacotherapy in resistant obsessive-compulsive disorder: a multicenter study. Psychother Psychosom 2012b; 81: 383-5.
Pallanti S, Quercioli L. Treatment-refractory obsessive-compulsive disorder: methodological issues, operational definitions and therapeutic lines. Prog Neuropsychopharmacol Biol Psychiatry 2006; 30: 400-12.
Fals-Stewart W, Marks AP, Schafer J. A comparison of behavioral group therapy and individual behavior therapy in treating obsessive-compulsive disorder. J Nerv Ment Dis 1993; 181: 189-93.
van Balkom AJ, de Haan E, van Oppen P, Spinhoven P, Hoogduin KA, van Dyck R. Cognitive and behavioral therapies alone versus in combination with fluvoxamine in the treatment of obsessive-compulsive disorder. J Nerv Ment Dis 1998; 186: 492-9.
Simpson HB, Gorfinkle KS, Liebowitz MR. Cognitive-behavioral therapy as an adjunct to serotonin reuptake inhibitors in obsessive-compulsive disorder: an open trial. J Clin Psychiatry 1999; 60: 584-90.
Kampman M, Keijsers GP, Hoogduin CA, Verbraak MJPM. Addition of cognitive-behaviour therapy for obsessive-compulsive disorder patients non-responding to fluoxetine. Acta Psychiatr Scand 2002; 106: 314-9.
Tolin DF, Maltby N, Diefenbach GJ, Hanna SE, Worhunsky P. Cognitive-behavioral therapy for medication nonresponders with obsessive-compulsive disorder: a wait-list-controlled open trial. J Clin Psychiatry 2004; 65: 922-31.
Anand N, Sudhir PM, Math SB, Thennarasu K, Janardhan Reddy YC. Cognitive behavior therapy in medication non-responders with obsessive-compulsive disorder: a prospective 1-year follow-up study. J Anxiety Disord 2011; 25: 939-45.
Simpson HB, Foa EB, Liebowitz MR, et al. Cognitive-behavioral therapy vs risperidone for augmenting serotonin reuptake inhibitors in obsessive-compulsive disorder: a randomized clinical trial. JAMA Psychiatry 2013; 70(11): 1190-9.
McLean CP, Zandberg LJ, Van Meter PE, Carpenter JK, Simpson HB, Foa EB. Exposure and response prevention helps adults with obsessive-compulsive disorder who do not respond to pharmacological augmentation strategies. J Clin Psychiatry 2015; 76(12): 1653-7.
Lindsay M, Crino R, Andrews G. Controlled trial of exposure and response prevention in obsessive-compulsive disorder. Br J Psychiatry 1997; 171: 135-9.
Franklin ME, Abramowitz JS, Kozak MJ, Foa EB. Effectiveness of exposure and ritual prevention for obsessive-compulsive disorder: randomized compared with non-randomized samples. J Consult Clin Psychol 2000; 68: 594-602.
Franklin ME, Abramowitz JS, Bux Jr DA, Zoellner LA, Feeny N. Cognitive-Behavioral Therapy with and without medication in the treatment of Obsessive-Compulsive Disorder. Prof Psychol Res Pract 2002; 33(2): 162-8.
McKay D, Sookman D, Neziroglu F, et al. Efficacy of cognitive-behavioral therapy for obsessive-compulsive disorder. Psychiatry Res 2015; 225(3): 236-46.
Simpson HB, Huppert JD, Petkova E, Foa EB, Liebowitz MR. Response versus remission in obsessive-compulsive disorder. J Clin Psychiatry 2006; 67: 269-76.
Simpson HB, Foa EB, Liebowitz MR, et al. A randomized, controlled trial of cognitive-behavioral therapy for augmenting pharmacotherapy in obsessive-compulsive disorder. Am J Psychiatry 2008; 165: 621-30.
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