Clinical and functional evaluation of bone marrow aspirate concentrate vs autologous conditioned serum in the treatment of knee osteoarthritis

Matteo Vitali; Marco  Ometti; Pierluigi Pironti; Damiano Salvato; Alice Sandrucci; Orlando Leone; Vincenzo Salini

doi:10.23750/abm.v93i5.12845

Clinical and functional evaluation of bone marrow aspirate concentrate vs autologous conditioned serum in the treatment of knee osteoarthritis

Authors

Matteo Vitali San Raffaele Scientific Institute, Department of Orthopedics and Traumatology (Milan, Italy)
Marco Ometti San Raffaele Scientific Institute, Department of Orthopedics and Traumatology (Milan, Italy)
Pierluigi Pironti a:1:{s:5:"en_US";s:34:"Università degli Studi di Milano ";}
Damiano Salvato San Raffaele University, Residency Program in Orthopedics and Traumatology (Milan, Italy);
Alice Sandrucci San Raffaele University (Milan, Italy)
Orlando Leone San Raffaele University, Residency Program in Orthopedics and Traumatology (Milan, Italy)
Vincenzo Salini San Raffaele Scientific Institute, Department of Orthopedics and Traumatology (Milan, Italy)

DOI: https://doi.org/10.23750/abm.v93i5.12845

Keywords:

Knee osteoarthritis; biological therapies; Bone Marrow Aspirate Concentrate; Autologous Conditioned Serum.

Abstract

Background and aim: The aim of this study was to compare the efficacy of a single Bone Marrow Aspirate Concentrate (BMAC) with a cycle of 4 Autologous Conditioned Serum (ACS) injections in the treatment of early-stage knee osteoarthritis (OA).

Methods: Two groups of 12 patients with degenerative knee OA were treated with a single BMAC injection and with a cycle of 4 ACS injections respectively. Follow-up was set at baseline (t0), one-month (t1) and six-months (t2) evaluating VAS for pain, WOMAC index and range of motion (ROM).

Results: We reported a significant improvement in WOMAC after BMAC injection both at t1 (p= 0,001) as well as t2 (p< 0,001), plus a reduction of VAS values in BMAC group at six months follow-up (p = 0,024). In contrast, no significant differences in ROM between the two groups were observed.

Conclusions: Both the approaches are safe and effective in the treatment of knee OA, with a major efficacy of BMAC.

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