Clinical and functional evaluation of bone marrow aspirate concentrate vs autologous conditioned serum in the treatment of knee osteoarthritis

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Matteo Vitali
Marco Ometti
Pierluigi Pironti
Damiano Salvato
Alice Sandrucci
Orlando Leone
Vincenzo Salini


Knee osteoarthritis; biological therapies; Bone Marrow Aspirate Concentrate; Autologous Conditioned Serum.


Background and aim: The aim of this study was to compare the efficacy of a single Bone Marrow Aspirate Concentrate (BMAC) with a cycle of 4 Autologous Conditioned Serum (ACS) injections in the treatment of early-stage knee osteoarthritis (OA).

Methods: Two groups of 12 patients with degenerative knee OA were treated with a single BMAC injection and with a cycle of 4 ACS injections respectively. Follow-up was set at baseline (t0), one-month (t1) and six-months (t2) evaluating VAS for pain, WOMAC index and range of motion (ROM).

Results: We reported a significant improvement in WOMAC after BMAC injection both at t1 (p= 0,001) as well as t2 (p< 0,001), plus a reduction of VAS values in BMAC group at six months follow-up (p = 0,024). In contrast, no significant differences in ROM between the two groups were observed.

Conclusions: Both the approaches are safe and effective in the treatment of knee OA, with a major efficacy of BMAC.


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