Recovery of gastric function in patients affected by chronic atrophic gastritis using l-cysteine (Acetium®): one year survey in comparison with a control group.: L-cysteine and Chronic Atrophic Gastritis

Recovery of gastric function in patients affected by chronic atrophic gastritis using l-cysteine (Acetium®): one year survey in comparison with a control group.

L-cysteine and Chronic Atrophic Gastritis

Authors

  • Pellegrino Crafa Department of Medicine and Surgery, University of Parma
  • Francesco Di Mario https://orcid.org/0000-0002-8189-7336
  • Simone Grillo Department of Medicine and Surgery, University of Parma; Parma - Italy
  • Stefano Landi Department of Medicine and Surgery, University of Parma
  • Marilisa Franceschi Endoscopy Unit, Department of Medicine, ULSS7 Pedemontana, Hospital AltoVicentino, Santorso (VI), Italy, Schio (Vi), IT
  • Kryssia Rodriguez-Castro Endoscopy Unit, Department of Medicine, ULSS7 Pedemontana, Hospital AltoVicentino, Santorso (VI), Italy, Schio (Vi), IT
  • Antonio Tursi Territorial Gastroenterology Service, Azienda Sanitaria Locale Barletta-Andria-Trani, Andria, Italy
  • Giovanni Brandimarte Division of Internal Medicine and Gastroenterology, Cristo Re Hospital, Rome, Italy
  • Lorella Franzoni Department of Medicine and Surgery, University of Parma

Keywords:

Pepsinogen I, Gastrin 17, Chronic atrophic Gastritis, L-cysteine, Acetaldehyde

Abstract

Background and aim: Chronic Atrophic Gastritis (CAG) is a precancerous condition for gastric cancer (GC) as single risk factor, being a consequence of a previous Helicobacter pylori (Hp) infection or based on autoimmune mechanisms. Achlorhydria plays an important role towards the formation of a class I carcinogen, acetaldehyde, after food intake. L-cysteine has been claimed to be able to bind in a covalent way acetaldehyde when administered at means.

Methods: In this study we enrolled two CAG groups of patients, one treated whit 300 mg/daily of L-cysteine for one year, the other one untreated.

We assessed gastric function lasting the one year follow-up by using non invasive surrogates, i.e. Pepsinogen I (PGI) and gastrin 17 (G17).

Results: In the group of 77 CAG on therapy we found a statistically significative increase in PGI values and a decrease in G17 levels, in comparison with unchanged values in control group.

Conclusions: L-cysteine seems able to provide a recovery in gastric function when administered in CAG patients and could be proposed as a possible therapy in such patients.

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01-07-2022

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1.
Crafa P, Di Mario F, Grillo S, et al. Recovery of gastric function in patients affected by chronic atrophic gastritis using l-cysteine (Acetium®): one year survey in comparison with a control group.: L-cysteine and Chronic Atrophic Gastritis. Acta Biomed. 2022;93(3):e2022184. doi:10.23750/abm.v93i3.12812