Cytological diagnosis of unifocal Langerhans cell histiocytosis in the temporomandibular joint.

Cytological diagnosis of unifocal Langerhans cell histiocytosis in the temporomandibular joint.

Authors

  • Dimitrios Tamiolakis
  • Aikaterini Charizani
  • Demosthenes Igoumenakis
  • Areti Volioti
  • Eleni Konsolaki
  • Alexandra Kalogeraki

Keywords:

Langerhans cell histiocytosis, Fine Needle aspiration, Cytology, Immunocytology, mandible, maxillofacial surgery, Magnetic Resonance Imaging

Abstract

Unifocal Langerhans cell histiocytosis (LCH) presents as a solitary focal bone lesion characterized by clonal proliferation of CD1a (+) and langerin(+) dendritic cells, derived from the bone marrow. In 38-69% of cases BRAF-V600E mutation is revealed. It gains attention to maxillofacial surgeons due to involvement of the orofacial region and early onset of jaws symptoms. If overlooked, massive deconstruction of tissues, occurs.

We present a case of LCH of the temporomandibular joint in a 14 aged child where fine needle aspiration favorably contributed in an accurate diagnosis combined with the appropriate clinicoradioliogical findings. This can overrule unwarranted biopsy and monitor the treatment largely where aproach to histopathology services is restricted.

References

Kumar N, Sayed S, Vinayak S. Diagnosis of Langerhans cell histiocytosis on fine needle aspiration cytology: A case report and review of the cytology literature. Patholog Res Int. 2011; 2011: 439518-439523

Stull MA, Kransdorf M, Devaney K. From the Archives of the AFIP. Langerhans Cell Histiocytosis of Bone. RadloGraphlcs 1992; 12:801-823

Park J , Chung J. Long-term treatment of Langerhans cell histiocytosis of the mandibular condyle with indomethacin. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010 Apr;109(4):e13-21.

Tamiolakis D , Barbagadaki S , Proimos E , Nikolaidou S , Chimona T S , Georgiou G , Perogamvrakis G, Papadakis CE. Touch imprint cytological diagnosis of nodal Langerhans cell histiocytosis. B-ENT 2009; 5: 115-118

Hwang DS, Lee JS, Kim UK, Park HR, Ryu MH, Lee JH, et al. Langerhans cell histiocytosis of the mandible: two case reports and literature review. J Korean Assoc Oral Maxillofac Surg 2019;45:167–72.

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Published

19-01-2022

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How to Cite

1.
Tamiolakis D, Charizani A, Igoumenakis D, Volioti A, Konsolaki E, Kalogeraki A. Cytological diagnosis of unifocal Langerhans cell histiocytosis in the temporomandibular joint. Acta Biomed [Internet]. 2022 Jan. 19 [cited 2024 Jul. 13];92(6):e2021430. Available from: https://mattioli1885journals.com/index.php/actabiomedica/article/view/12084