COVID-19 vaccine effectiveness among the staff of the Bologna Health Trust, Italy, December 2020-April 2021
Keywords:
COVID-19, vaccine effectiveness, health care workersAbstract
Background and aim:
Randomized controlled trials have shown that mRNA vaccines are highly effective in preventing SARS-CoV2 infection. We conducted a study to assess the real-world effectiveness of mRNA vaccines (Pfizer-BioNTech or Moderna) in preventing all and symptomatic SARS-CoV2 infections and COVID-19 related hospitalizations in the staff of the Bologna Health Trust (HT), Italy
Methods:
We followed up retrospectively 9839 staff of the Bologna HT from December 27, 2020 to April 3, 2020 and calculated the effectiveness in partially and fully vaccinated subjects by applying a multivariable Cox proportional hazard model.
Results:
Vaccine effectiveness in preventing SARS-CoV2 infections is 85.5% (95%CI: 75.9-91.3) in the partially vaccinated and 84.8% (95%CI: 73.2-91.4) in the fully vaccinated. In preventing symptomatic infection effectiveness is 81.7% (95%CI: 62.7-91.0) in the partially and 87.1% (95%CI: 69.3-94.6) in the fully vaccinated. There were no COVID-19-related hospitalizations in the partially or fully vaccinated vs 15 hospitalization in the unvaccinated cohort.
Conclusions:
Our results confirm the effectiveness of mRNA vaccines in a real-world setting in Northern Italy.
References
References
WHO. Weekly Operational Update on COVID-19. Issue No. 57, May 31, 2021
Signorelli C, Scognamiglio T, Odone A. COVID-19 in Italy: impact of containment measures and prevalence estimates of infection in the general population. Acta Biomed 2020; 91(3-S): 175-179.
Bo Y, Guo C, Lin C et al. Effectiveness of non-pharmaceutical interventions on COVID-19 transmission in 190 countries from 23 January to 13 April 2020. Int J Infect Dis 2021; 102: 247-253.
Kim HHS, Laurence J. COVID-19 restrictions and mental distress among American adults: evidence from Corona Impact Survey (W1 and W2). J Public Health 2020; 42(4): 704-711.
Polack FP, Thomas SJ, Kitchin N et al. Safety and efficacy of the BNT162b2 mRNA Covid-19 vaccine. N Engl J Med 2020; 383(27): 2603-15.
Baden LR, El Sahly HM, Essink B et al. Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine. N Engl J Med 2021; 384(5): 403-416.
Angel Y, Spitzer A, Henig O et al. Association Between Vaccination With BNT162b2 and Incidence of Symptomatic and Asymptomatic SARS-CoV-2 Infections Among Health Care Workers. JAMA 2021, May 6.
Fabiani M, Ramigni M, Gobbetto V, Mateo-Urdiales A, Pezzotti P, Piovesan C.
Effectiveness of the Comirnaty (BNT162b2, BioNTech/Pfizer) vaccine in preventing SARS-CoV-2 infection among healthcare workers, Treviso province, Veneto region, Italy, 27 December 2020 to 24 March 2021. Euro Surveill 2021; 26(17): 2100420.
Hall VJ, Foulkes S, Saei A, Andrews N et al. COVID-19 vaccine coverage in health-care workers in England and effectiveness of BNT162b2 mRNA vaccine against infection (SIREN): a prospective, multicentre, cohort study. Lancet 2021 8; 397(10286): 1725-1735.
Thompson MG, Burgess JL, Naleway AL et al. Interim Estimates of Vaccine Effectiveness of BNT162b2 and mRNA-1273 COVID-19 Vaccines in Preventing SARS-CoV-2 Infection Among Health Care Personnel, First Responders, and Other Essential and Frontline Workers - Eight U.S. Locations, December 2020-March 2021. MMWR 2021; 70(13): 495-500.
Dagan N, Barda N, Kepten E et al. BNT162b2 mRNA Covid-19 Vaccine in a Nationwide Mass Vaccination Setting. N Engl J Med 2021; 384: 1412-1423.
Abo SMC, Smith SR. Is a COVID-19 Vaccine Likely to Make Things Worse? Vaccines 2020; 8(4): 761.
Benenson S, Oster Y, Cohen MJ. BNT162b2 mRNA Covid-19 Vaccine Effectiveness among Health Care Workers. N Engl J Med 2021; 384: 1775-1777.
Ausl di Bologna. Report COVID 19 Comune di Bologna 17-25 aprile. https://www.ausl.bologna.it/per-i-cittadini/coronavirus/rcps (accessed on May 5, 2021)
RER. Ordinanza del presidente della Giunta Regionale N.68. Bologna, 30 aprile 2021.
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