A prospective multicentric study of risk-reducing salpingo-oophorectomy in BRCA mutation patients Risk-reducing salpingo-oophorectomy in BRCA mutations

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Vera Loizzi
Ettore Cicinelli
Vittoria Del Vecchio
Francesca Arezzo
Xheni Deromemaj
Anila Kardhashi
Angelo Paradiso
Francesco Legge
Maria Iole Natalicchio
Leonardo Resta
Nicoletta Resta
Daria Carmela Loconte
Gennaro Cormio


BRCA, ovarian cancer, risk-reducing surgery, genetical screening, cancer prevention


Background and aim of the work: BRCA1/2 are tumour-suppressor genes involved in DNA homologous recombination and ovarian cancer development.  The study evaluated the risk of tumor cancer in women presenting the BRCA mutations.

Methods: Risk-reducing surgery (RRS) was performed in 100 patients carrying BRCA1 (aged between 30-73 years, median age was 51 years) and BRCA 2 mutation (aged between 36-70 years, median age was 53 years). Fifty-eight patients had previous history of breast cancer.

Results: Between the 100 patients, 82 women underwent risk-reducing salpingo-oophorectomy (RRSO) through a laparoscopic minimally invasive approach, 7 (7 %) underwent laparoscopic RRSO and contextual hysterectomy, 1 woman (1 %) underwent RRSO through a laparotomic approach and 10 women (10 %) laparotomic RRSO and hysterectomy. During 5 (5 %) laparoscopic RRSO, prophylactic bilateral mastectomy was also performed. Early and late complication occurred in 3 patients (3 %). Two patients (2 %) were found to have occult Serous Tubal Intraepithelial Carcinoma (STIC) and three patients (3 %) occult cancer.

Conclusions: RRSO is safe and feasible in BRCA mutation carriers. The procedure is effective for genetic prevention of ovarian cancer.


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