Use of MicroRNAs as biomarkers in the early diagnosis of prostate cancer

Use of MicroRNAs as biomarkers in the early diagnosis of prostate cancer

Authors

  • Duran Canatan
  • Ozlem Yılmaz Antalya Genetic Diseases – Antalya- Turkey
  • Yonca Sonmez Akdeniz University, Faculty of Medicine, Department of Public Health – Antalya- Turkey
  • Abdullah Cim Antalya Genetic Diseases Center – Antalya- Turkey
  • Mehmet Baykara Lara Anadolu Hospital, Department of Urology- Antalya
  • Murat Savas Memorial Hospital, Department of Urology- Antalya
  • Hasan Senol Coskun Akdeniz University, Faculty of Medicine, Department of Medical Oncology- Antalya- Turkey
  • Sema Sezgin Goksu Akdeniz University, Faculty of Medicine, Department of Medical Oncology- Antalya- Turkey
  • Mehmet Rıfkı Aktekin Akdeniz University, Faculty of Medicine, Department of Public Health – Antalya- Turkey

Keywords:

Prostate cancer, biomarker, microRNA

Abstract

Introduction: Prostate cancer (PCa) is a common type of cancer in western countries and prominent cause of mortality in men. The aim of the study was to analyze circulating miRNAs as biomarkers in the sera of healthy individuals and prostate cancer cases without biopsy.

Material and methods: Twenty prostate cases, age (mean and range) 61,4±12.1 (45-73), and twenty healthy men, age 59,3±11.2 (44-70) were included to the study. The mean and range of prostate spesific antigen (PSA) in cancer cases and healthy individuals were 6.79±2.84 ng/ml (2.25-14.7) and 3.8±2.2 ng/ml (1.3-7.8) respectively.

Results: Seven miRNAs including two internal controls (Let7c, miR125b, miR141, miR145, miR 155, miR181 ve miR192) were evaluated in two groups. The level of miR141 was significantly lower in PCa cases than healthy individuals (p=0,004), and miR155 was significantly higher (p=0,005) in PCa cases. Both miRNAs were explored sensitive and spesific in the ROC analysis. Tumor mass were found to be associated with the level of miR-125b and miR-145.

Conclusion; validation studies are required in wider patient groups in the subject of tumor effect and miRNA biomarkers in prostate cancer.

References

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Published

01-07-2022

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ORIGINAL ARTICLES

How to Cite

1.
Canatan D, Yılmaz O, Sonmez Y, et al. Use of MicroRNAs as biomarkers in the early diagnosis of prostate cancer. Acta Biomed. 2022;93(3):e2022089. doi:10.23750/abm.v93i3.11642