Prognostic factors in clear cell carcinoma of endometrium: analysis of 55 cases

Vera Loizzi; Ettore Cicinelli; Achiropita Lepera; Francesco Legge; Massimiliano Memmola; Giulia Chiarello; Francesca Arezzo; Vittoria Del Vecchio; Leonardo Resta; Gennaro Cormio

doi:10.23750/abm.v92i6.11336

Prognostic factors in clear cell carcinoma of endometrium: analysis of 55 cases

Authors

Vera Loizzi Interdisciplinar Department of Medicine, Obstetrics and Gynecology Unit, University of Bari “Aldo Moro”, Piazza Giulio Cesare 11, 70124 Bari, Italy
Ettore Cicinelli Department of Biomedical Sciences and Human Oncology, University of Bari, Italy Piazza Giulio Cesare 11, Bari Italy
Achiropita Lepera Department of Biomedical Sciences and Human Oncology, University of Bari, Italy Piazza Giulio Cesare 11, Bari Italy
Francesco Legge Gynecologic Oncology Unit, General Regional Hospital “F. Miulli” of Acquaviva delle Fonti, Italy Strada Prov. 127 Acquaviva – Santeramo Km. 4, 70021 Acquaviva delle Fonti BA Italy
Massimiliano Memmola Department of Biomedical Sciences and Human Oncology, University of Bari, Italy Piazza Giulio Cesare 11, Bari Italy
Giulia Chiarello Department of Biomedical Sciences and Human Oncology, University of Bari, Italy Piazza Giulio Cesare 11, Bari Italy
Francesca Arezzo a:1:{s:5:"en_US";s:116:"Department of Biomedical Sciences and Human Oncology, University of Bari, Italy Piazza Giulio Cesare 11, Bari Italy ";}
Vittoria Del Vecchio Department of Biomedical Sciences and Human Oncology, University of Bari, Italy Piazza Giulio Cesare 11, Bari Italy
Leonardo Resta Department of Pathology, University of Bari, Italy, Piazza Giulio Cesare 11, Bari Italy
Gennaro Cormio Department of Biomedical Sciences and Human Oncology, University of Bari, Italy Piazza Giulio Cesare 11, Bari Italy

DOI: https://doi.org/10.23750/abm.v92i6.11336

Keywords:

prognostic factors, clear cell carcinoma of endometrium, endometrial cancer; stage, survival, recurrence.

Abstract

Background and aim of the work: The purpose of this study was to evaluate the clinical and pathologic prognostic factors associated with survival in patients with clear cell carcinoma (CCC) of the endometrium. Methods: A retrospective review of fifty-five patients with endometrial clear cell carcinoma were collected. Results: The median overall and disease-free survivals were 40 and 20 months, respectively. A univariate analysis was performed with respect to stage of disease, age, lymph nodes status, myometrium invasion, lymph vascular space invasion and adjuvant therapy. Stage was found to be the only important prognostic factor related to survival. In fact, early stage had a median survival of 77 months compared to 34 months in the advanced disease (p<0.04). These differences remained significant after adjusting for single stage (stage III versus IV). Conclusions: Endometrial CCC is a rare histotype. Advanced stage disease is considered a poor prognostic factor. Recurrences are high even in early stage. Randomized clinical trials are needed.

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