Autologous Platelet Rich Plasma (PRP) in the treatment of elbow epicondylitis and plantar fasciitis: medium to long term clinical outcome: PRP in P. Fasciitis and epicondylitis

Autologous Platelet Rich Plasma (PRP) in the treatment of elbow epicondylitis and plantar fasciitis: medium to long term clinical outcome

PRP in P. Fasciitis and epicondylitis


  • Massimiliano Leigheb Orthopaedics and Traumatology, A.O.U. "Maggiore d.c."Universiy of Eastern Piedmont, Novara
  • Matteo MASSA Department of Orthopaedics and Traumatology, “Maggiore della Carità” Hospital, Department of Health Sciences, University of Piemonte Orientale (UPO), Novara, Italy. Specialization School in Orthopaedics and Traumatology, University of Pavia, Pavia, Italy.
  • Michela BOSETTI Department of “Scienze del Farmaco”, University of Eastern Piedmont, Novara, Italy.
  • Piergiuseppe NICO Department of Orthopaedics and Traumatology, “Maggiore della Carità” Hospital, Department of Health Sciences, University of Piemonte Orientale (UPO), Novara, Italy.
  • Luigi TARALLO Department of Orthopedics and Traumatology, Policlinico di Modena Hospital, University of Modena and Reggio Emilia, Modena, Italy.
  • Francesco POGLIACOMI Orthopaedic Clinic, Department of Medicine and Surgery, University Hospital of Parma, Parma, Italy.
  • Federico Alberto GRASSI Department of Orthopaedics and Traumatology, “Maggiore della Carità” Hospital, Department of Health Sciences, University of Piemonte Orientale (UPO), Novara, Italy.


PRP, Platelet Rich Plasma, epicondylitis, plantar fasciitis, regenerative medicine, growth factors.


Background and aim:

Platelet-Rich-Plasma (PRP) is a popular biological therapy especially used to regenerate different musculoskeletal tissues by releasing growth-factors and cytokines promoting cell proliferation, chemotaxis, differentiation, and angiogenesis.

The aim was to evaluate the clinical effectiveness and safety of PRP for Lateral-Epicondylitis (LE) of the elbow and Plantar-Fasciitis (PF).


A retrospective study was conducted including patients treated with a single topic autologous-PRP-injection between 1-1-2009 and 7-18-2019 for LE or PF at our institution; patients operated for the same problem, patients refusing the study or not traceable were excluded. Patients were assessed with VAS for pain and clinical scales.


33 patients were treated with PRP and 13 (8F, 5M) included: 4LE and 9PF for a total of 16 cases. The average pain level was 0.61±0.63: 1±1.41 for LE and 0,44±0 for PF. No significant side effect was reported. 4 PRP-treatments failed: 2LE and 2PF. OES and PRTEE gave excellent results for elbow. Average foot scores were AOFAS 98.2±5 and FADI 91.3±1. Patients were stratified and compared according to plantar arch conformation, follow-up length, healing time, time from diagnosis to PRP-treatment, therapies before PRP (physiotherapy, steroid infiltration or shock-waves), risk factors (standing work, sport, age, sex).


As in other studies, our results do not allow to draw sufficiently valid conclusions regarding the effectiveness and safety of PRP in the treatment of LE and PF: in particular the statistical significance is limited by the small sample size. PRP can be chosen as a non-first-line treatment for LE and PF.


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How to Cite

Autologous Platelet Rich Plasma (PRP) in the treatment of elbow epicondylitis and plantar fasciitis: medium to long term clinical outcome: PRP in P. Fasciitis and epicondylitis. Acta Biomed [Internet]. 2020 Dec. 30 [cited 2024 Jun. 18];91(14-S):e2020029. Available from:

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