The synergic use of the High Power Laser Therapy and Glucosamine sulfate in Knee osteoarthritis: A Randomized Controlled Trial

The synergic use of the High Power Laser Therapy and Glucosamine sulfate in Knee osteoarthritis: A Randomized Controlled Trial


  • Antonio Ammendolia a:1:{s:5:"en_US";s:23:"University of Catanzaro";}
  • Nicola Marotta Department of Surgical and Medical Sciences, University of Catanzaro “Magna Graecia” Italy
  • Cinzia Marinaro Department of Surgical and Medical Sciences, University of Catanzaro “Magna Graecia” Italy
  • Andrea Demeco Department of Surgical and Medical Sciences, University of Catanzaro “Magna Graecia” Italy
  • Paolo Mondardini Department of Sport Science, Bologna, Italy
  • Cosimo Costantino Department of Medicine and Surgery, University of Parma, Parma, Italy


High Power Laser Therapy, glucosamine sulfate, knee osteoarthritis


Background and aim: To determine the efficacy of the synergistic use of High Power Laser Therapy (HPLT) with glucosamine sulfate (GS) in knee osteoarthritis.

Methods: This 2-arm randomized controlled trial (RCT) enrolled 90 subjects (M=53, F=37, y= 55±11.2) and randomly allocated using a stratified sampling method in experimental group (A) with HPLT+GS 1500mg (GS - Dona®, Rottapharm, Monza, Italy) (n=45) or in a control group (B) with HPLT + placebo (n=45). 

Results: VAS score in Activities of day Living (ADL), Standardized stair climb test (SSCT), Zohlen’s sign (RASPING) and Rabot test were used, to evaluate patients at the beginning of the study (T0), at 2 months (T1) and at 6 months (T2). In the mean scores for VAS in ADL, SSCT, RABOT and RASPING at T1, no significant differences were found between the experimental and the control group with paired T and ANOVA test. But significant differences between groups (p<0.05) in all outcomes were observed at 6 months (T2).

Conclusions: HPLT is useful in treating knee osteoarthritis, but when combined with Glucosamine Sulfate, thanks to the synergy of two interventions, can achieve a long-term effect up to 6 months after treatment


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The synergic use of the High Power Laser Therapy and Glucosamine sulfate in Knee osteoarthritis: A Randomized Controlled Trial. Acta Biomed [Internet]. 2021 Jul. 1 [cited 2024 Jun. 23];92(3):e2021237. Available from: