The synergic use of the High Power Laser Therapy and Glucosamine sulfate in Knee osteoarthritis: A Randomized Controlled Trial

Antonio Ammendolia; Nicola Marotta; Cinzia  Marinaro; Andrea Demeco; Paolo Mondardini; Cosimo Costantino

doi:10.23750/abm.v92i3.10952

The synergic use of the High Power Laser Therapy and Glucosamine sulfate in Knee osteoarthritis: A Randomized Controlled Trial

Authors

Antonio Ammendolia a:1:{s:5:"en_US";s:23:"University of Catanzaro";}
Nicola Marotta Department of Surgical and Medical Sciences, University of Catanzaro “Magna Graecia” Italy
Cinzia Marinaro Department of Surgical and Medical Sciences, University of Catanzaro “Magna Graecia” Italy
Andrea Demeco Department of Surgical and Medical Sciences, University of Catanzaro “Magna Graecia” Italy
Paolo Mondardini Department of Sport Science, Bologna, Italy
Cosimo Costantino Department of Medicine and Surgery, University of Parma, Parma, Italy

DOI: https://doi.org/10.23750/abm.v92i3.10952

Keywords:

High Power Laser Therapy, glucosamine sulfate, knee osteoarthritis

Abstract

Background and aim: To determine the efficacy of the synergistic use of High Power Laser Therapy (HPLT) with glucosamine sulfate (GS) in knee osteoarthritis.

Methods: This 2-arm randomized controlled trial (RCT) enrolled 90 subjects (M=53, F=37, y= 55±11.2) and randomly allocated using a stratified sampling method in experimental group (A) with HPLT+GS 1500mg (GS - Dona®, Rottapharm, Monza, Italy) (n=45) or in a control group (B) with HPLT + placebo (n=45).

Results: VAS score in Activities of day Living (ADL), Standardized stair climb test (SSCT), Zohlen’s sign (RASPING) and Rabot test were used, to evaluate patients at the beginning of the study (T0), at 2 months (T1) and at 6 months (T2). In the mean scores for VAS in ADL, SSCT, RABOT and RASPING at T1, no significant differences were found between the experimental and the control group with paired T and ANOVA test. But significant differences between groups (p<0.05) in all outcomes were observed at 6 months (T2).

Conclusions: HPLT is useful in treating knee osteoarthritis, but when combined with Glucosamine Sulfate, thanks to the synergy of two interventions, can achieve a long-term effect up to 6 months after treatment

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