Exploring the emergence of vertical transmission of SARS-CoV-2: A Rapid Review Exploring the emergence of vertical transmission of SARS-CoV-2:

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Vidhi Jain http://orcid.org/0000-0002-0180-6175
Tanuj Kanchan https://orcid.org/0000-0003-0346-1075
Kewal Krishan http://orcid.org/0000-0001-5321-0958


Amniotic fluid; vertical transmission; SARS-CoV-2; COVID-19 pandemic


Novel Coronavirus, SARS-CoV-2 is responsible for the global pandemic of COVID-19. It has been shown to spread through respiratory droplets, direct contact and environmental fomites. The possibility of its spread by other modes viz. airborne, fecal-oral, vertical, etc. is being explored and can have implications in planning preventive strategies and disease management. A systematic analysis was carried out using the keywords; “COVID 19 vertical transmission”, “SARS-CoV-2 pregnancy”, and “SARS-CoV-2 vertical transmission”, and the cases suggestive of possible vertical transmission of SARS-CoV-2 were studied in detail. The available evidences point at a possibility of vertical transmission of SARS-CoV-2.


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1. Chan JFW, Yuan S, Kok KH, To KKW, Chu H, Yang J et al. A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster. Lancet 2020; 395:514-523.
2. WHO, World Health Organization, Transmission of SARS-CoV-2: implications for infection prevention precautions, Available at: https://www.who.int/news- room/commentaries/detail/transmission-of-sars-cov-2-implications-for-infection- prevention-precautions, 2020 (Accessed on 23th October 2020).
3. van Doremalen N, Bushmaker T, Morris DH, et al. Aerosol and surface stability of SARS-CoV-2 as compared with SARS-CoV-1. N Engl J Med 2020;382:1564-1567. https://doi.org/10.1056/NEJMc2004973.
4. Morawska L, Cao J. 2020. Airborne transmission of SARS-CoV-2: the world should face the reality. Environ Int 2020; 139:105730.
5. Morawska L, Milton DK. It is Time to Address Airborne Transmission of COVID-19. Clin Infect Dis 2020;ciaa939. https://doi.org/10.1093/cid/ciaa939
6. Mukhra R, Krishan K, Kanchan T. Possible modes of transmission of Novel coronavirus SARS-CoV-2: a review. Acta Bio Med 2020;91(3):e2020023, https://mattioli1885journals.com/index.php/actabiomedica/article/view/10039.
7. Dashraath P, Wong JLJ, Lim MXK, Lim LM, Li S, Biswas A et al. Coronavirus Disease 2019 (COVID-19) Pandemic and Pregnancy. Am J Obstet Gynecol 2020; 222(6):521-531, DOI: 10.1016/j.ajog.2020.03.021.
8. Pradhan P, Pandey AK, Mishra A, Gupta P, Tripathi PK, Menon MB, Gomes J, Vivekanandan P, Kundu B. Uncanny similarity of unique inserts in the 2019-nCoV spike protein to HIV-1 gp120 and Gag. bioRxiv 2020: 2020.01.30.927871, DOI: 10.1101/2020.01.30.927871.
9. World Health Organization. (‎2020)‎. Laboratory testing strategy recommendations for COVID-19: interim guidance, 21 March 2020. World Health Organization. https://apps.who.int/iris/handle/10665/331509. License: CC BY-NC- SA 3.0 IGO. (Accessed on 23th October 2020).
10. Tang YW, Schmitz JE, Persing DH, Stratton CW. Laboratory Diagnosis of COVID- 19: Current Issues and Challenges. J Clin Microbiol 2020;58(6):e00512-20.
11. Wang S, Guo L, Chen L, Liu W, Cao Y, Zhang J, Feng L. A case report of neonatal COVID-19 infection in China. Clin Infect Dis 2020;71(15):853-857.
12. Dong L, Tian J, He S, et al. Possible vertical transmission of SARS- CoV-2 from an infected mother to her newborn. JAMA 2020; 323(18):1846-1848, DOI: 10.1001/jama.2020.4621.
13. Zeng H, Xu C, Fan J, et al. Antibodies in infants born to mothers with COVID-19 pneumonia. JAMA 2020; 26;323(18):1848-9. DOI: 10.1001/ jama.2020.4861.
14. Alzamora MC, Paredes T, Caceres D, Webb CM, Valdez LM, La Rosa M. Severe COVID-19 during Pregnancy and Possible Vertical Transmission. Am J Perinatol 2020; 37(8):861-865, doi:10.1055/s-0040-1710050.
15. Zamaniyan M, Ebadi A, Aghajanpoor Mir S, Rahmani Z, Haghshenas M, Azizi S. Preterm delivery, maternal death, and vertical transmission in a pregnant woman with COVID‐19 infection. Prenat Diagn 2020;10.1002/pd.5713. doi:10.1002/pd.5713.
16. Dumpa V, Kamity R, Vinci AN, Noyola E, Noor A. Neonatal Coronavirus 2019 (COVID-19) Infection: A Case Report and Review of Literature. Cureus 2020;12(5):e8165, doi:10.7759/cureus.8165
17. Piersigilli F, Carkeek K, Hocq C, et al. COVID-19 in a 26-week preterm neonate. Lancet Child Adolesc Health 2020;4(6):476‐478.
18. Yu N, Li W, Kang Q, et al. Clinical features and obstetric and neonatal outcomes of pregnant patients with COVID-19 in Wuhan, China: a retrospective, single-centre, descriptive study. Lancet Infect Dis. 2020;20(5):559-564. doi:10.1016/S1473- 3099(20)30176-6.
19. Di Mascio D, Khalil A, Saccone G, Rizzo G, Buca D, Liberati M et al. Outcome of Coronavirus spectrum infections (SARS, MERS, COVID-19) during pregnancy: a systematic review and meta-analysis. Am J Obstet Gynecol MFM 2020; 2(2):100107. doi:10.1016/j.ajogmf.2020.100107.
20. Yang Z, Liu Y. Vertical Transmission of Severe Acute Respiratory Syndrome Coronavirus 2: A Systematic Review. Am J Perinatol 2020;37(10):1055-1060. doi:10.1055/s-0040-1712161.
21. Kotlyar A, Grechukhina O, Chen A, Popkhadze S, Grimshaw A, Tal O, Taylor HS, Tal R. Vertical Transmission of COVID-19: A Systematic Review and Meta-analysis, Am J Obstet Gynecol 2020, doi: https://doi.org/10.1016/j.ajog.2020.07.049.
22. Panchaud A, Favre G, Pomar L, Vouga M, Aebi-Popp K, Baud D et al. An international registry for emergent pathogens and pregnancy. Lancet 2020;395(10235):1483‐1484. doi:10.1016/S0140-6736(20)30981-8.