Distrectual osteosarcopenia in limb disuse: case report and mini literature review

Main Article Content

Gabriele Filoni https://orcid.org/0000-0002-5060-4908
Michele Di Lonardo
Giovanni Mandile
Lorenzo Andreani
Francesca Falossi
Alessandro Franchi
Vanna Bottai
Rodolfo Capanna

Keywords

Osteoporosis, osteosarcopenia, disuse, BMU

Abstract

Osteosarcopenia is a new concept of association of osteoporosis and sarcopenia. Both of these pathologies are more frequent in old people and general affects all the skeleton with increased risk of falls and fractures, loss of global function, fragility, and mortality, but also surgical failures.


The coexistence of these condition derives from a close relationship, not only anatomical, between bone and muscle tissues. Sometimes these pathological conditions can involve only a skeleton segment, due to local disuse, causing a district form of sarcopenia. In this clinical case, Authors describes a case of isolated lower limb osteosarcopenia in a young non-osteoporotic patient, due to a prolonged limb disuse, complicated by surgical treatment failure for previous pathology, diagnosed by clinical, laboratory, instrumental and histopathological exams.

Downloads

Download data is not yet available.
Abstract 123 | PDF Downloads 94

References

[1] H. P. Hirschfeld, R. Kinsella, e G. Duque, «Osteosarcopenia: where bone, muscle, and fat collide», Osteoporos. Int. J. Establ. Result Coop. Eur. Found. Osteoporos. Natl. Osteoporos. Found. USA, vol. 28, n. 10, pagg. 2781–2790, 2017, doi: 10.1007/s00198-017-4151-8.
[2] C. Beaudart et al., «Sarcopenia in daily practice: assessment and management», BMC Geriatr., vol. 16, n. 1, pag. 170, dic. 2016, doi: 10.1186/s12877-016-0349-4.
[3] J. A. Kanis, C. Cooper, R. Rizzoli, J.-Y. Reginster, e Scientific Advisory Board of the European Society for Clinical and Economic Aspects of Osteoporosis (ESCEO) and the Committees of Scientific Advisors and National Societies of the International Osteoporosis Foundation (IOF), «European guidance for the diagnosis and management of osteoporosis in postmenopausal women», Osteoporos. Int. J. Establ. Result Coop. Eur. Found. Osteoporos. Natl. Osteoporos. Found. USA, vol. 30, n. 1, pagg. 3–44, gen. 2019, doi: 10.1007/s00198-018-4704-5.
[4] H. Okamura et al., «Risk factors predicting osteosarcopenia in postmenopausal women with osteoporosis: A retrospective study», PLOS ONE, vol. 15, pag. e0237454, ago. 2020, doi: 10.1371/journal.pone.0237454.
[5] O. Fricke e E. Schoenau, «The ‘Functional Muscle-Bone Unit’: Probing the relevance of mechanical signals for bone development in children and adolescents», Growth Horm. IGF Res., vol. 17, n. 1, pagg. 1–9, feb. 2007, doi: 10.1016/j.ghir.2006.10.004.
[6] H. M. Frost e E. Schönau, «The “Muscle-Bone Unit” in Children and Adolescents: A 2000 Overview», J. Pediatr. Endocrinol. Metab., vol. 13, n. 6, gen. 2000, doi: 10.1515/JPEM.2000.13.6.571.
[7] J. Paintin, C. Cooper, e E. Dennison, «Osteosarcopenia», Br. J. Hosp. Med., vol. 79, n. 5, pagg. 253–258, mag. 2018, doi: 10.12968/hmed.2018.79.5.253.
[8] S. Hong e W. H. Choi, «The effects of sarcopenia and obesity on femur neck bone mineral density in elderly Korean men and women», Osteoporos. Sarcopenia, vol. 2, n. 2, pagg. 103–109, giu. 2016, doi: 10.1016/j.afos.2016.04.002.
[9] O. M. Steihaug, C. G. Gjesdal, B. Bogen, M. H. Kristoffersen, G. Lien, e A. H. Ranhoff, «Sarcopenia in patients with hip fracture: A multicenter cross-sectional study», PLOS ONE, vol. 12, n. 9, pag. e0184780, set. 2017, doi: 10.1371/journal.pone.0184780.
[10] R. M. Y. Wong et al., «The relationship between sarcopenia and fragility fracture-a systematic review», Osteoporos. Int. J. Establ. Result Coop. Eur. Found. Osteoporos. Natl. Osteoporos. Found. USA, vol. 30, n. 3, pagg. 541–553, mar. 2019, doi: 10.1007/s00198-018-04828-0.
[11] E. A. Greco, P. Pietschmann, e S. Migliaccio, «Osteoporosis and Sarcopenia Increase Frailty Syndrome in the Elderly», Front. Endocrinol., vol. 10, apr. 2019, doi: 10.3389/fendo.2019.00255.
[12] Y.-J. Wang et al., «Sarco-Osteoporosis: Prevalence and Association with Frailty in Chinese Community-Dwelling Older Adults», Int. J. Endocrinol., vol. 2015, pag. 482940, 2015, doi: 10.1155/2015/482940.
[13] B. Kirk, A. Al Saedi, e G. Duque, «Osteosarcopenia: A case of geroscience», AGING Med., vol. 2, n. 3, pagg. 147–156, set. 2019, doi: 10.1002/agm2.12080.
[14] M. Fatima, S. L. Brennan-Olsen, e G. Duque, «Therapeutic approaches to osteosarcopenia: insights for the clinician», Ther. Adv. Musculoskelet. Dis., vol. 11, pag. 1759720X1986700, gen. 2019, doi: 10.1177/1759720X19867009.
[15] J.-I. Yoo e Y.-C. Ha, «Review of Epidemiology, Diagnosis, and Treatment of Osteosarcopenia in Korea», J. Bone Metab., vol. 25, n. 1, pag. 1, 2018, doi: 10.11005/jbm.2018.25.1.1.
[16] N. Bonnet, L. Bourgoin, E. Biver, E. Douni, e S. Ferrari, «RANKL inhibition improves muscle strength and insulin sensitivity and restores bone mass», J. Clin. Invest., vol. 129, n. 8, pagg. 3214–3223, ago. 2019, doi: 10.1172/JCI125915.
[17] F. Lauretani et al., «Age-associated changes in skeletal muscles and their effect on mobility: an operational diagnosis of sarcopenia», J. Appl. Physiol. Bethesda Md 1985, vol. 95, n. 5, pagg. 1851–1860, nov. 2003, doi: 10.1152/japplphysiol.00246.2003.
[18] S. Giannotti et al., «Disuse osteoporosis of the upper limb: assessment of thirty patients», Clin. Cases Miner. Bone Metab., vol. 10, n. 2, pagg. 129–132, 2013.
[19] E. Neri, A. D’Arienzo, V. Bottai, L. Andreani, S. Giannotti, e C. Rodolfo, «DISUSE OSTEOPOROSIS AND HIP PROSTHESIS: SURGICAL IMPLICATIONS, A CASE REPORT», EuroMediterranean Biomed. J., vol. 15, pagg. 74–76, giu. 2020, doi: 10.3269/1970-5492.2020.15.17.

Most read articles by the same author(s)