Polyphenols, Olive oil and Colonrectal cancer: the effect of Mediterranean Diet in the prevention

Main Article Content

Anna Vittoria Mattioli
Francesco Serra
Francesco Spatafora
Silvia Toni
Alberto Farinetti
Roberta Gelmini

Keywords

cancer, Mediterranean Diet, polyphenols, olive oil

Abstract

In recent years, scientific research has shown that the incidence of various diseases, including some cancers, is relatively low in the Mediterranean Countries compared to that of other European countries or North America. This support the hypothesis that the Mediterranean diet, rich in bioactive food components, including methyl group donors, polyphenols, and fatty acids has efficacy in terms of prevention.


Few studies evaluated the efficacy of Med Diet on colon cancer however they all support the beneficial effects of this Diet in preventing cancer.


 

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References

1. Farinetti A, Zurlo V, Manenti A, Coppi F, Mattioli AV. Mediterranean diet and colorectal cancer: A systematic review. Nutrition 2017: 43-44, 83-88.
2. Truzzi ML, Ballerini Puviani M, Tripodi A, Farinetti A, Nasi M, Mattioli AV. Mediterranean Diet as a model of sustainable, resilient and healthy diet. Progress in nutrition 2020 vol 2; 2 doi: 10.23751/pn.v22i2.8634
3. Reddavide R, Rotolo O, Caruso MG, et al. The role of diet in the prevention and treatment of Inflammatory Bowel Diseases. Acta Bio Med [Internet]. 2018Dec.17 [cited 2020Jul.23];89(9-S):60-5. Available from: https://www.mattioli1885journals.com/index.php/actabiomedica/article/view/7952
4. Mattioli AV, Coppi F, Migaldi M, Scicchitano P, Ciccone MM, Farinetti A. Relationship between Mediterranean diet and asymptomatic peripheral arterial disease in a population of pre-menopausal women. Nutr Metab Cardiovasc Dis. 2017; 27(11):985-990. doi: 10.1016/j.numecd.2017.09.011
5. Alam MN, Almoyad M, Huq F. Polyphenols in Colorectal Cancer: Current State of Knowledge including Clinical Trials and Molecular Mechanism of Action. Biomed Res Int. 2018; 8:415-4185. doi: 10.1155/2018/4154185. eCollection 2018.
6. Mattioli AV, Migaldi M, Farinetti A. Coffee in hypertensive women with asymptomatic peripheral arterial disease: a potential nutraceutical effect. J Cardiovasc Med 2018; 19(4):183-185. doi: 10.2459/JCM.0000000000000626
7. Hosseinzadeh E, Hassanzadeh A, Marofi F, Alivand MR, Solali S. Flavonoid-Based Cancer Therapy: An Updated Review [published online ahead of print, 2020 Apr 22]. Anticancer Agents Med Chem. 2020;10.2174/1871520620666200423071759. doi:10.2174/1871520620666200423071759
8. Torić J, Brozovic A, Baus Lončar M, et al. Biological Activity of Phenolic Compounds in Extra Virgin Olive Oils through Their Phenolic Profile and Their Combination with Anticancer Drugs Observed in Human Cervical Carcinoma and Colon Adenocarcinoma Cells. Antioxidants (Basel). 2020 May 24;9(5):453. doi: 10.3390/antiox9050453.
9. Karković Marković A, Torić J, Barbarić M, Jakobušić Brala C. Hydroxytyrosol, Tyrosol and Derivatives and Their Potential Effects on Human Health. Molecules. 2019 May 24;24(10):2001. doi: 10.3390/molecules24102001
10. Torić J, Marković AK, Brala CJ, Barbarić M. Anticancer effects of olive oil polyphenols and their combinations with anticancer drugs. Acta Pharm. 2019 Dec 1;69(4):461-482. doi: 10.2478/acph-2019-0052
11. Gorzynik-Debicka M, Przychodzen P, Cappello Fet al. Potential Health Benefits of Olive Oil and Plant Polyphenols. Int J Mol Sci. 2018 Feb 28;19(3):686. doi: 10.3390/ijms19030686. PMID: 29495598; PMCID: PMC5877547.
12. Della Valle PG, Mosconi G, Nucci D, et al Adherence to the Mediterranean Diet during the COVID-19 national lockdowns: a systematic review of observational studies. Acta Biomed. 2021 Oct 19;92(S6):e2021440. doi: 10.23750/abm.v92iS6.12233. PMID: 34739464.
13. Ruiz-Roso MB, Padilha P de C, Mantilla-Escalante DC, et al. Covid-19 confinement and changes of adolescent’s dietary trends in Italy, Spain, Chile, Colombia and Brazil. Nutrients. 2020;12(6).
14. Mattioli AV, Nasi M, Cocchi C, Farinetti A. COVID-19 outbreak: impact of the quarantine-induced stress on cardiovascular disease risk burden. Future Cardiol. 2020 Nov;16(6):539-542. doi: 10.2217/fca-2020-0055. Epub 2020 Apr 30.
15. Cipolla C, Curatola A, Ferretti S, et al. Eating habits and lifestyle in children with obesity during the COVID19 lockdown: a survey in an Italian center. Acta Biomed. 2021 May 12;92(2):e2021196. doi: 10.23750/abm.v92i2.10912.
16. Bracale R, Vaccaro CM. Changes in food choice following restrictive measures due to Covid-19. Nutr Metab Cardiovasc Dis. 2020 Aug 28;30(9):1423-1426. doi: 10.1016/j.numecd.2020.05.027. Epub 2020 May 30.
17. Polyphenols in Olive Related Health Claims. Available online: https://www.efsa.europa.eu/it/efsajournal/ pub/2033
18. Di Francesco A, Falconi A, Di Germanio C, et al. Extravirgin olive oil up-regulates CB₁ tumor suppressor gene in human colon cancer cells and in rat colon via epigenetic mechanisms. J Nutr Biochem. 2015; 26(3):250-8. doi: 10.1016/j.jnutbio.2014.10.013. Epub 2014 Dec 3
19. Pampaloni B, Mavilia C, Fabbri S, et al. In vitro effects of extracts of extra virgin olive oil on human colon cancer cells. Nutr Cancer 2014; 66(7):1228-36. doi: 10.1080/01635581.2014.951727. Epub 2014 Sep 10.
20. Hashim YZ, Worthington J, Allsopp P, et al. Virgin olive oil phenolics extract inhibit invasion of HT115 human colon cancer cells in vitro and in vivo. Food Funct. 2014; 25;5(7):1513-9. doi: 10.1039/c4fo00090k.
21. Salvini S, Sera F, Caruso D, et al. Daily consumption of a high-phenol extra-virgin olive oil reduces oxidative DNA damage in postmenopausal women. Br J Nutr 2006.;95(4):742-51
22. Mattioli AV, Coppi F, Migaldi M, Farinetti A. Fruit and vegetables in hypertensive women with asymptomatic peripheral arterial disease. Clinical Nutrition ESPEN 2018; 27: 110-112
23. de la Torre R. Bioavailability of olive oil phenolic compounds in humans. Inflammopharmacology 2008;16(5):245-7. doi: 10.1007/s10787-008-8029-4.
24. Borzì AM, Biondi A, Basile F, Luca S, Vicari ESD, Vacante M. Olive Oil Effects on Colorectal Cancer. Nutrients 2018.;11(1). pii: E32. doi: 10.3390/nu11010032.
25. Zamora-Ros R, Cayssials V, Jenab M et al. Dietary intake of total polyphenol and polyphenol classes and the risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Eur J Epidemiol. 2018 May 15. doi:10.1007/s10654-018-0408-6.
26. Isomura K, Kono S, Moore MA, et al. Physical activity and colorectal cancer: the Fukuoka Colorectal Cancer Study. Cancer Sci 2006;97(10):1099-104. Epub 2006 Aug 17.
27. Agnoli C, Sieri S, Ricceri F, et al. Adherence to a Mediterranean diet and long-term changes in weight and waist circumference in the EPIC-Italy cohort. Nutr Diabetes. 2018; 25;8(1):22. doi: 10.1038/s41387-018-0023-3.
28. Boronat A, Martínez-Huélamo M, Cobos A, de la Torre R. Wine and Olive Oil Phenolic Compounds Interaction in Humans. Diseases 2018. 1;6(3). pii: E76. doi: 10.3390/diseases6030076.
29. Mattioli AV, Farinetti A. Gelmini R. The beneficial effect of Mediterranean diet on colorectal cancer. Inter J Cancer 2019; 145, 306
30. Sciomer S, Moscucci F, Maffei S, Gallina S, Mattioli AV. Cardiovascular risk factors prevention in women: the life style paradox and stereotypes to defeat. Eur J Prev Cardiol. 2019;26(6):609-610. doi: 10.1177/2047487318810560
31. Campesi I, Marino M, Cipolletti M, Romani A, Franconi F. Put "gender glasses" on the effects of phenolic compounds on cardiovascular function and diseases. Eur J Nutr 2018;57(8):2677-2691. doi: 10.1007/s00394-018-1695-0. Epub 2018 Apr 25.
32. Chen Y, Wu Y, Du M, et al. An inverse association between tea consumption and colorectal cancer risk. Oncotarget. 2017;8(23):37367-37376. doi:10.18632/oncotarget.16959
33. Cui WQ, Wang ST, Pan D, Chang B, Sang LX. Caffeine and its main targets of colorectal cancer. World J Gastrointest Oncol. 2020;12(2):149-172. doi:10.4251/wjgo.v12.i2.149
34. Mattioli AV, Farinetti A. Espresso coffee, caffeine and colon cancer. World J Gastrointest Oncol. 2020;12(5):601-603. doi:10.4251/wjgo.v12.i5.601
35. Corona G, Deiana M, Incani A, Vauzour D, Dessì MA, Spencer JP. Inhibition of p38/CREB phosphorylation and COX-2 expression by olive oil polyphenols underlies their anti-proliferative effects. Biochem Biophys Res Commun. 2007 Oct 26;362(3):606-11. doi: 10.1016/j.bbrc.2007.08.049.
36. Notarnicola M, Pisanti S, Tutino V, et al. Effects of olive oil polyphenols on fatty acid synthase gene expression and activity in human colorectal cancer cells. Genes Nutr. 2011 Feb;6(1):63-9. doi: 10.1007/s12263-010-0177-7. Epub 2010 May 16.
37. Khanal P, Oh WK, Yun HJ,et al. p-HPEA-EDA, a phenolic compound of virgin olive oil, activates AMP-activated protein kinase to inhibit carcinogenesis. Carcinogenesis. 2011 Apr;32(4):545-53. doi: 10.1093/carcin/bgr001. Epub 2011 Jan 7.

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