Asthma in children and adolescents: the ControL’Asma project

Main Article Content

Amelia Licari https://orcid.org/0000-0002-1773-6482
Giorgio Ciprandi
Gian Luigi Marseglia
Michela Silvestri
Maria Angela Tosca
Elisa Anastasio
Ilaria Brambilla
Carlo Caffarelli
Riccardo Castagnoli
Loredana Chini
Riccardo Ciprandi
Valentina De Vittori
Marzia Duse
Maria Elisa Di Cicco
Luciana Indinnimeo
Ahmad Kantar
Maddalena Leone
Guido Marinelli
Viviana Moschese
Roberta Olcese
Diego G Peroni
Angela Pistorio
Claudia Salmaso
Anna Maria Zicari

Keywords

asthma, asthma control, children, adolescents, VAS, respiratory symptoms, lung function

Abstract

The control of asthma is the objective of asthma management. However, it is difficult to obtain in clinical practice. The Italian Society of Allergy and Clinical Immunology promoted the nationwide project “ControL’Asma” to investigate the real situation in a group of children and adolescents with asthma. The preliminary outcomes demonstrated that many asthmatic subjects do not achieve adequate asthma control. Moreover, asthma in Italian children and adolescents was usually more frequent in males, had an early onset and allergic phenotype with very frequent rhinitis comorbidity, uncontrolled and partly controlled asthma affected about the half of subjects. However, this project suggested that the assessment of asthma symptom perception by VAS could be a reliable tool in the asthma management.

a

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...
Abstract 9 | PDF Downloads 6

References

1) Chipps BE, Bacharier LB, Farrar JR, et al. The pediatric asthma yardstick. Ann Allergy Asthma Immunol 2018;120:559-79.
2) Global Initiative for Asthma. Global strategy for asthma management and prevention, 2019. Available from: www.ginasthma.org
3) Akar-Ghibril N, Casale T, Custovic A, Phipatanakul W. Allergic endotypes and phenotypes of asthma. J Allergy Clin Immunol Pract 2020;8:429-40.
4) Licari A, Castagnoli R, Brambilla I, et al. Asthma endotyping and biomarkers in childhood asthma. Pediatr Allergy Immunol Pulmonol 2018;31:44-55.
5) Di Cicco M, D’Elios S, Peroni DG, Comberiati P. The role of atopy in asthma development and persistence. Curr Opin Allergy Clin Immunol 2020;20:131-137.
6) British Thoracic Society; Scottish Intercollegiate Guidelines Network. British guideline on the management of asthma. Thorax. 2014;69 Suppl 1:1–192.
7) Australian Asthma Handbook Melbourne: National Asthma Council, Australia. https://www.asthmahandbook.org.au
8) NICE. Asthma: diagnosis, monitoring, and chronic asthma management. NICE guideline. https://www.nice.org.uk/guidance/ng80
9) Zahran HS, Bailey CM, Qin X, Johnson C. Long-term control medication use and asthma control status among children and adults with asthma. J Asthma 2017;54:1065-72
10) Bloomberg GR, Banister C, Sterkel R, Epstein J, Bruns J, Swerczek L, Wells S, et al. Socioeconomic, family, and pediatric practice factors that affect level of asthma control. Pediatrics 2009;123:829–35
11) Bårnes CB, Ulrik CS. Asthma and adherence to inhaled corticosteroids: current status and future perspectives. Respir Care 2015;60:455–68.
12) Engelkes M, Janssens HM, de Jongste JC, Sturkenboom MC, Verhamme KM. Medication adherence and the risk of severe asthma exacerbations: a systematic review. Eur Respir J 2015;45:396–407.
13) Reddel HK, Taylor R, Bateman ED, et al. An official American Thoracic Society/European Respiratory Society Statement: asthma control and exacerbations. Am J Respir Crit Care Med 2009;180:59-99.
14) Virchow JC, Backer V, de Blay F, et al. Defining moderate asthma exacerbations in clinical trials based on the ATS/ERS joint statement. Resp Med 2015;109:547-56.
15) Williams SA, Wagner S, Kannan H, Bolge SC. The association between asthma control and healthcare utilization, work productivity loss, and health-related quality of life. J Occup Environ Med 2009;51:780–5.
16) Licari A, Brambilla I, Marseglia A, De Filippo M, Paganelli V, Marseglia GL. Difficult vs. severe asthma: definition and limits of asthma control in the pediatric population. Front Pediatr 2018;6:170.
17) Licari A, Manti S, Castagnoli R, et al. Immunomodulation in pediatric asthma. Front Pediatr 2019;7:289.
18) Sherman RE, Anderson SA, Dal Pan GJ, et al. Real-world evidence—what is it and what can it tell us? N Engl J Med 2016; 375:2293-7.
19) Milger K, Korn S, Buhl R, et al. Age- and sex-dependent differences in patients with severe asthma included in the German asthma net cohort. Resp Med 2020;162:105858.
20) Ciprandi G, Gallo F. The impact of gender on asthma in the daily practice. Postgrad Med 2018;130:271-3.
21) Tosca MA, Silvestri M, Olcese R, Pistorio A, Rossi GA, Ciprandi G. Breathlessness perception assessed by visual analogue scale and lung function in children with asthma: a real-life study. Ped Allergy Immunol 2012;23:537-42.
22) Tosca MA, Silvestri M, Rossi GA, Ciprandi G. Perception of bronchodilation assessed by Visual Analogue Scale in children with asthma. Allergol Immunopathol 2013;41:359-63.
23) Bousquet J, Anto JM, Bachert C, et al. From ARIA Guidelines to the digital transformation of health in rhinitis and asthma multimorbidity. Eur Respir J 2019;54:1901023.
24) Brew BK, Chiesa F, Lundholm C, Ortqvist A, Almqvist C. A modern approach to identifying and characterizing child asthma and wheeze phenotypes based on clinical data. Plos One 2019;14:e0227091.
25) Mastrorilli C, Posa D, Cipriani F, Caffarelli C. Asthma and allergic rhinitis in childhood: what’s new. Pediatr Allergy Immunol 2016: 27: 795–803.
26) Licari A, Manti S, Castagnoli R, et al. Targeted therapy for severe asthma in children and adolescents: current and future perspectives. Paediatr Drugs 2019;21:215-237. doi:10.1007/s40272-019-00345-7.
27) Licari A, Castagnoli R, Panfili E, Marseglia A, Brambilla I, Marseglia GL. An update on Anti-IgE therapy in pediatric respiratory diseases. Curr Respir Med Rev 2017;13:22-29. doi:10.2174/1573398X13666170616110738.
28) Licari A, Castagnoli R, Brambilla I, et al. New approaches for identifying and testing potential new anti-asthma agents. Expert Opin Drug Discov 2018;13(1):51-63. doi:10.1080/17460441.2018.1396315.
29) Kaplan A, Price D. Treatment adherence in adolescents with asthma. J Asthma Allergy 2020;13:39-49.
30) Hoch de Keyser H, Ramsey R, Federico MJ. They just don’t take their medicine: reframing medication adherence in asthma from frustration to opportunity. Pediatr Pulmonol 2020;55:818-25.
31) Weinberger SJ, Cowan KJ, Robinson KJ, et al. A primary care learning collaborative to improve office systems and clinical management of pediatric asthma. J Asthma 2019;1-10. [published online ahead of print, 2019 Dec 14]. doi:10.1080/02770903.2019.1702199.
32) Ciprandi G, Gallo F, Ricciardolo F. A real-life comparison between Asthma Control Test and GINA asthma control grading. Annals Allergy Asthma Immunol 2016;117:725-7.

Most read articles by the same author(s)