Progressive Disseminated Histoplasmosis in an Immunocompetent Host: A Rare Presentation of an Uncommon Disease

Mehul Agarwal; Manohar Lal Gupta; Benhur Joel Shadrach; Neha  Bharti

doi:10.23750/abm.v92iS1.10213

Progressive Disseminated Histoplasmosis in an Immunocompetent Host: A Rare Presentation of an Uncommon Disease

Authors

Mehul Agarwal Department of Pulmonary Medicine, All India Institute of Medical Sciences (AIIMS), Jodhpur
Manohar Lal Gupta Department of Pulmonary Medicine,Santokba Durlabhji Memorial Hospital, Jaipur
Benhur Joel Shadrach Pulmonary, Critical care & Sleep Medicine, Department of Pulmonary Medicine, All India Institute of Medical Sciences (AIIMS), Jodhpur
Neha Bharti Department of Anesthesiology and critical care, All India Institute of Medical Sciences (AIIMS), Jodhpur

DOI: https://doi.org/10.23750/abm.v92iS1.10213

Keywords:

Disseminated Histoplasmosis, endemic, immunocompetent, biopsy

Abstract

Disseminated Histoplasmosis, a systemic fungal infection caused by Histoplasma capsulatum is predominantly seen in immunocompromised cases. It is usually endemic, although sporadic cases have been reported. Following initial infection to the lungs, it disseminates to various organs by lymphatic and hematogenous routes. Clinical features are non-specific and depend on the extent and severity of organ involvement. A Biopsy is required for diagnosis and timely intervention decreases morbidity and mortality. Our case report describes an atypical association of progressive disseminated Histoplasmosis with bone marrow involvement in an immunocompetent adult from a non-endemic region and alerts the clinicians to a rare yet life-threatening mycosis.

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