Is a strict cow’s milk-free diet necessary to treat milk oral immunotherapy-related eosinophilic esophagitis?

Annamaria Bianchi; Mauro Calvani; Lucia Leonardi; Danilo Remotti; Roberto Paparella

doi:10.23750/abm.v92i3.10050

Is a strict cow’s milk-free diet necessary to treat milk oral immunotherapy-related eosinophilic esophagitis?

Authors

Annamaria Bianchi a:1:{s:5:"en_US";s:41:"Azienda Ospedaliera San Camillo Forlanini";}
Mauro Calvani U.O.C. di Pediatria, Azienda Ospedaliera San Camillo Forlanini, Roma, Italia
Lucia Leonardi Dipartimento di Pediatria, Università Sapienza, Roma, Italia
Danilo Remotti U.O.C di Anatomia Patologica, Azienda Ospedaliera San Camillo Forlanini, Roma, Italia
Roberto Paparella Dipartimento di Pediatria, Università Sapienza, Roma, Italia

DOI: https://doi.org/10.23750/abm.v92i3.10050

Keywords:

eosinophilic esophagitis; oral immunotherapy; cow's milk hypersensitivity

Abstract

We report the case of a 15-year-old boy who developed eosinophilic esophagitis (EoE) during cow’s milk oral immunotherapy (CM-OIT). In order to not completely invalidate OIT benefits, baked milk-containing foods were allowed instead of a strict CM-free diet. However, histological remission of EoE was reached only after a strict cow’s milk-free diet, not associated to pharmacological treatment. Nevertheless, given the limited data on real incidence of food OIT related EoE and potential beneficial treatment for this condition, we highlight the need of prospective studies aimed to evaluate if a strict CM free diet in OIT related EoE is always necessary to obtain remission of the disease or similarly to CM EoE, baked milk-containing foods” diet could be abeneficial treatment also in these patients.

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