The relationship between clinicopathology factors and omental metastasis in epithelial ovarian cancer

The relationship between clinicopathology factors and omental metastasis in epithelial ovarian cancer

Authors

  • Sigit Purbadi Gynecology Oncology Division, Obstetrics and Gynecology Department, Medical Faculty,Universitas Indonesia
  • Hariyono Winarto Gynecology Oncology Division, Obstetrics and Gynecology Department, Medical Faculty, Universitas Indonesia
  • Febian Nathania Department of Obstetrics and Gynecology, Medical Faculty, Universitas Indonesia

Keywords:

Clinicopathology factors; epithelial ovarian cancer; omentum; omental metastasis

Abstract

Background: Aside from being a major metastatic site in epithelial type ovarian cancer, omentum has an immunological role. Omentum has the ability to colonize the spread of cancer cells by forming omental caking. This study aims to determine the relationship between clinicopathology factors with metastasis in omentum in epithelial type ovarian cancer.

Methods: The study used cross-sectional study design. Subjects were patients diagnosed with epithelial type ovarian cancer who underwent surgery at Cipto Mangunkusumo Hospital between January 2010 and December 2017.

Results: There was an association between serous as well as mucinous type, omental nodules, and between CA 125 and metastasis in omentum (OR 1.7, CI 95% 24.1-47.7; p = 0.002, OR 14.5, CI 95% 2.5- 82.2; p = 0.002, OR 61, CI 95% 11.4-324.8; p <0.01, and OR 3.5, CI 95% 1.2-9.7; p = 0.013). Multivariate analysis demonstrated a significant association between mucinous types with metastases in the omentum (aOR 9.71, CI 95% 1.11-84.89; p = 0.04) and between the omental nodules and metastases in the omentum (aOR 40.92, CI 95% 6.64-251.96 ; p <0.01).

Conclusion: The incidence of omental metastasis in epithelial ovarian cancer is higher in mucinous histological types of and omental nodules only.

Author Biographies

Sigit Purbadi, Gynecology Oncology Division, Obstetrics and Gynecology Department, Medical Faculty,Universitas Indonesia

Background: Aside from being a major metastatic site in epithelial type ovarian cancer, omentum has an immunological role. Omentum has the ability to colonize the spread of cancer cells by forming omental caking. This study aims to determine the relationship between clinicopathology factors with metastasis in omentum in epithelial type ovarian cancer. Methods: The study used cross-sectional study design. Subjects were patients diagnosed with epithelial type ovarian cancer who underwent surgery at Cipto Mangunkusumo Hospital between January 2010 and December 2017. Results: There were association between serous as well as mucinous type, omental nodules, and between CA 125 and metastasis in omentum (OR 1.7, CI 95% 24.1-47.7; p=0.002, OR 14.5, CI 95% 2.5-82.2; p=0.002, OR 61, CI 95% 11.4-324.8; p<0.01, and OR 3.5, CI 95% 1.2-9.7; p=0.013). Multivariate analysis demonstrated a significant association between mucinous types with metastases in the omentum (aOR 9.71, CI 95% 1.11-84.89; p=0.04) and between the omental nodules and metastases in the omentum (aOR 40.92, CI 95% 6.64-251.96 ; p <0.01). Conclusions: The incidence of omental metastasis in epithelial ovarian cancer is higher in mucinous histological types of and omental nodules only.

Hariyono Winarto, Gynecology Oncology Division, Obstetrics and Gynecology Department, Medical Faculty, Universitas Indonesia

Hariyono Winarto  is a consultant in gynecology oncology division of obstetrics and gynecology. His doctoral program in biomedics, Universitas Indonesia. He had followed surgical  training  in  gynecologic oncology and  laparoscopy in UMC Utrecht, The Netherlands, IGCS and also followed research  fellowship  in  Biomedics,  Asia  Link  Programme, pathology departement of Leids Universitair Medisch Centrum, Leiden, The Netherlands. After completing an obstetric and gynecology specialist education at  medical faculty, Universitas Indonesia, he continued his sub-specialist education in gynecology oncology at medical faculty, Univesitas Indonesia. Now, he is staff of  gynecologic oncology Division,obstetrics and gynecology department, faculty of medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo hospital. Besides, he also member of several organisation, such as  Indonesian Society of Gynecologic Oncology (INASGO), International Gynecology Cancer Society (IGCS), European Society of Gynecologic Oncology (ESGO), ASIAN Society of Gynecologic Oncology (Asian SGO), member of Indonesian Gynecologic Endoscopy Society (IGES),  Asia Pacific Association of Gynecologic Endoscopy (APAGE), American Association Gynecologic Laparoscopy (AAGL), and Faculty of ICTEC (Indonesian Clinical. He already published 27 national and international research publication and 38 times had  experiences as peer reviewer .

 

 

Febian Nathania, Department of Obstetrics and Gynecology, Medical Faculty, Universitas Indonesia

She is a last year resident of obstetrics and gynecology, medical faculty, Universitas Indonesia. After graduating from a medical education from medical faculty, Universitas Trisakti, Indonesia,  she continued her education in obstetrics and gynecology specialist at medical faculty, Universitas Indonesia. She is interested in oncology gynecology topics.

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Published

2019-09-12

Issue

European Journal of Oncology Vol.23, No.4 (2018)

Section

Articles on original studies and research

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How to Cite

1.
Purbadi S, Winarto H, Nathania F. The relationship between clinicopathology factors and omental metastasis in epithelial ovarian cancer. Eur J Oncol Env Hea [Internet]. 2019 Sep. 12 [cited 2025 May 21];23(4):198-203. Available from: https://mattioli1885journals.com/index.php/EJOEH/article/view/8058

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