VEGF gene +936C/T polymorphism decreases the risk of colorectal cancer

VEGF gene +936C/T polymorphism decreases the risk of colorectal cancer

Authors

  • Sanaz Savabkar Basic and Molecular Epidemiology of Gastrointestinal Disorder Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  • Vahid Chaleshi Basic and Molecular Epidemiology of Gastrointestinal Disorder Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  • Faegheh Behboudi Farahbakhsh Basic and Molecular Epidemiology of Gastrointestinal Disorder Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  • Mahdi Montazer Haghighi Biology Department, Faculty of Science, East Tehran Branch, Islamic Azad University, Tehran, Iran.
  • Neda Zali Basic and Molecular Epidemiology of Gastrointestinal Disorder Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  • Ehsan Nazemalhosseini Mojarad Gastroenterology and Liver Diseases Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Mohsen Vahedi Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
  • Gholam Reza Javadi Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran.
  • Hamid Asadzade Aghdaei Basic and Molecular Epidemiology of Gastrointestinal Disorder Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Mohammad Reza Zali Gastroenterology and Liver Diseases Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Keywords:

VEGF, angiogenesis, 3΄UTR, CRC, SNP, genotypes

Abstract

Background/aims: Vascular endothelial growth factor (VEGF) is a signal protein and plays a main role in angiogenesis and metastasis of tumors. Some variation in 3΄untranslated region (3΄UTR) of VEGF gene could alter the expression of this gene. In this study we have evaluated the possible association between +936C/T (rs3025039) polymorphism located in 3΄UTR of VEGF gene and the risk of colorectal cancer (CRC) in an Iranian population.

Methods: In the present case-control study, VEGF genotypes of +936C/T polymorphism were determined in 200 patients with CRC and 200 control individuals. DNA was extracted from blood specimens and genotypes were analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method.

Results: A significant correlation was found between+ 936C/T variant in the VEGF gene and CRC risk. Frequency of TT genotype was 16% in control and 2% in case study. There was a statistically significant difference in TT genotype frequency between CRC patients and control individuals (adjusted OR= 0.229, 95% CI= 0.058-0.899; P=0.035).

Conclusions: These results suggest that TT genotype may have a protective effect against colorectal cancer in an Iranian population.

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Published

2015-10-15

Issue

European Journal of Oncology Vol.20, No 2 (2015)

Section

Research

License

OPEN ACCESS

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How to Cite

1.
Savabkar S, Chaleshi V, Behboudi Farahbakhsh F, Montazer Haghighi M, Zali N, Nazemalhosseini Mojarad E, et al. VEGF gene +936C/T polymorphism decreases the risk of colorectal cancer. Eur J Oncol Env Hea [Internet]. 2015 Oct. 15 [cited 2025 Apr. 10];20(2):88-93. Available from: https://mattioli1885journals.com/index.php/EJOEH/article/view/4116