VEGF gene +936C/T polymorphism decreases the risk of colorectal cancer

VEGF gene +936C/T polymorphism decreases the risk of colorectal cancer

Authors

  • Sanaz Savabkar Basic and Molecular Epidemiology of Gastrointestinal Disorder Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  • Vahid Chaleshi Basic and Molecular Epidemiology of Gastrointestinal Disorder Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  • Faegheh Behboudi Farahbakhsh Basic and Molecular Epidemiology of Gastrointestinal Disorder Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  • Mahdi Montazer Haghighi Biology Department, Faculty of Science, East Tehran Branch, Islamic Azad University, Tehran, Iran.
  • Neda Zali Basic and Molecular Epidemiology of Gastrointestinal Disorder Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  • Ehsan Nazemalhosseini Mojarad Gastroenterology and Liver Diseases Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Mohsen Vahedi Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
  • Gholam Reza Javadi Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran.
  • Hamid Asadzade Aghdaei Basic and Molecular Epidemiology of Gastrointestinal Disorder Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Mohammad Reza Zali Gastroenterology and Liver Diseases Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Keywords:

VEGF, angiogenesis, 3΄UTR, CRC, SNP, genotypes

Abstract

Background/aims: Vascular endothelial growth factor (VEGF) is a signal protein and plays a main role in angiogenesis and metastasis of tumors. Some variation in 3΄untranslated region (3΄UTR) of VEGF gene could alter the expression of this gene. In this study we have evaluated the possible association between +936C/T (rs3025039) polymorphism located in 3΄UTR of VEGF gene and the risk of colorectal cancer (CRC) in an Iranian population.

Methods: In the present case-control study, VEGF genotypes of +936C/T polymorphism were determined in 200 patients with CRC and 200 control individuals. DNA was extracted from blood specimens and genotypes were analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method.

Results: A significant correlation was found between+ 936C/T variant in the VEGF gene and CRC risk. Frequency of TT genotype was 16% in control and 2% in case study. There was a statistically significant difference in TT genotype frequency between CRC patients and control individuals (adjusted OR= 0.229, 95% CI= 0.058-0.899; P=0.035).

Conclusions: These results suggest that TT genotype may have a protective effect against colorectal cancer in an Iranian population.

Downloads

Published

2015-10-15

Issue

European Journal of Oncology Vol.20, No 2 (2015)

Section

Research

License

OPEN ACCESS

All the articles of the European Journal of Oncology and Environmental Health are published with open access under the CC-BY Creative Commons attribution license (the current version is CC-BY, version 4.0 http://creativecommons.org/licenses/by/4.0/). This means that the author(s) retain copyright, but the content is free to download, distribute and adapt for commercial or non-commercial purposes, given appropriate attribution to the original article.

The articles in the previous edition of the Journal (European Journal of Oncology) are made available online with open access under the CC-BY Creative Commons attribution license (the current version is CC-BY, version 4.0 http://creativecommons.org/licenses/by/4.0/).

Upon submission, author(s) grant the Journal the license to publish their original unpublished work within one year, and the non exclusive right to display, store, copy and reuse the content. The CC-BY Creative Commons attribution license enables anyone to use the publication freely, given appropriate attribution to the author(s) and citing the Journal as the original publisher. The CC-BY Creative Commons attribution license does not apply to third-party materials that display a copyright notice to prohibit copying. Unless the third-party content is also subject to a CC-BY Creative Commons attribution license, or an equally permissive license, the author(s) must comply with any third-party copyright notices.

How to Cite

1.
Savabkar S, Chaleshi V, Behboudi Farahbakhsh F, Montazer Haghighi M, Zali N, Nazemalhosseini Mojarad E, et al. VEGF gene +936C/T polymorphism decreases the risk of colorectal cancer. Eur J Oncol Env Hea [Internet]. 2015 Oct. 15 [cited 2025 Apr. 2];20(2):88-93. Available from: https://mattioli1885journals.com/index.php/EJOEH/article/view/4116