Polymorphisms and haplotypes of XRCC1 and APE1 and risk of childhood leukaemia in China: a case-control analysis

Main Article Content

Ren Zhu
Department of Occupational Health and Toxicology, School of Public Health, Fudan University, Shanghai, China

Yuxia Wu
Department of Occupational Health and Toxicology, School of Public Health, Fudan University, Shanghai, China

Fen-juan Lu
Department of Occupational Health and Toxicology, School of Public Health, Fudan University, Shanghai, China

Ai-hong Wang
Department of Occupational Health and Toxicology, School of Public Health, Fudan University, Shanghai, China

Jing-yang Tang
Shanghai Children’s Medical Center, Shanghai, China

Jin-cai Zhao
Shanghai Children’s Medical Center, Shanghai, China

Chao Chen
Paediatric Hospital, Fudan University, Shanghai, China

Zhao-lin Xia
Department of Occupational Health and Toxicology, School of Public Health, Fudan University, Shanghai, China

Keywords

childhood leukaemia, genetic polymorphism, DNA repair

Abstract

Aims. To explore the relationship between genetic polymorphism of DNA repair and susceptibility to childhood leukaemia. Materials and methods. A hospital-based case-control study, with 105 cases and 108 controls, was conducted, to analyze the distribution of X-ray radiation, polymorphisms of XRCC1 and APE1 in study subjects, and investigate the interaction between X-ray radiation and polymorphisms. Results. There was an increased risk of leukaemia in children exposed to X-ray radiation. XRCC1 399 and APE1 148 polymorphisms are related to susceptibility to acute leukaemia (OR=2.05, 95%CI 1.14-3.70; OR=1.94, 95%CI 1.05-3.58), while no gene-environment interaction effect was found. The analysis of haplotypes of polymorphisms in XRCC1 showed that children carrying Hap2 and Hap4 had an increased risk of leukaemia (OR=2.88, 95%CI 1.58-5.25; OR=3.76, 95%CI 1.17-12.08). Conclusion. Polymorphisms of XRCC1 and APE1 involved in base excision repair might influence the repair of DNA damage and the susceptibility to childhood leukaemia.
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Published
Sep 1, 2008

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1.
Polymorphisms and haplotypes of XRCC1 and APE1 and risk of childhood leukaemia in China: a case-control analysis. Eur J Oncol [Internet]. 2008 Sep. 1 [cited 2024 Nov. 15];13(3):187-92. Available from: https://mattioli1885journals.com/index.php/EJOEH/article/view/3926
Issue
European Journal of Oncology Vol.13, No.3 (2008)
Section
Articles on original studies and research

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How to Cite

1.
Polymorphisms and haplotypes of XRCC1 and APE1 and risk of childhood leukaemia in China: a case-control analysis. Eur J Oncol [Internet]. 2008 Sep. 1 [cited 2024 Nov. 15];13(3):187-92. Available from: https://mattioli1885journals.com/index.php/EJOEH/article/view/3926

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