Serum amyloid A in lung transplantation

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Lucia Vietri
Department of Medical and Surgical Sciences and Neurosciences, Respiratory Disease and Lung Transplant Unit, University of Siena, AOUS, Siena, Italy

Elena Bargagli
Department of Medical and Surgical Sciences and Neurosciences, Respiratory Disease and Lung Transplant Unit, University of Siena, AOUS, Siena, Italy

David Bennett
Department of Medical and Surgical Sciences and Neurosciences, Respiratory Disease and Lung Transplant Unit, University of Siena, AOUS, Siena, Italy

Antonella Fossi
Paolo Cameli
Department of Medical and Surgical Sciences and Neurosciences, Respiratory Disease and Lung Transplant Unit, University of Siena, AOUS, Siena, Italy

Laura Bergantini
Department of Medical and Surgical Sciences and Neurosciences, Respiratory Disease and Lung Transplant Unit, University of Siena, AOUS, Siena, Italy

Miriana d’Alessandro
Department of Medical and Surgical Sciences and Neurosciences, Respiratory Disease and Lung Transplant Unit, University of Siena, AOUS, Siena, Italy

Piero Paladini
Thoracic Surgery Unit, Department of Medicine, Surgery and Neuroscences, Siena University Hospital Siena, Italy

Luca Luzzi
Thoracic Surgery Unit, Department of Medicine, Surgery and Neuroscences, Siena University Hospital Siena, Italy

Francesco Gentili
Department of Medical, Surgical and Neuro Sciences, Diagnostic Imaging, University of Siena, Azienda Ospedaliera Universitaria Senese, Siena, Italy

Maria Antonietta Mazzei
Department of Medical, Surgical and Neuro Sciences, Diagnostic Imaging, University of Siena, Azienda Ospedaliera Universitaria Senese, Siena, Italy

Donatella Spina
Pathology Unit, Siena University Hospital Siena, Italy

Piersante Sestini
Department of Medical and Surgical Sciences and Neurosciences, Respiratory Disease and Lung Transplant Unit, University of Siena, AOUS, Siena, Italy

Paola Rottoli
Department of Medical and Surgical Sciences and Neurosciences, Respiratory Disease and Lung Transplant Unit, University of Siena, AOUS, Siena, Italy

Keywords

serum amyloid A, serum biomarkers, lung transplantation

Abstract

Background: Serum Amyloid A (SAA) is an acute phase protein and we analyzed its concentrations in lung transplantated patients (LTX). Methods: 26 LTX patients (58.6 ± 11 years) and 11 healthy controls (55 ± 11.3 years). Three groups of LTX patients: acute rejection (AR, 7) bronchiolitis obliterans syndrome (BOS, 3), acute infection (INF, 9) and stable patients (NEG, 7). Results: In LTX patients SAA concentrations were significantly increased, particularly in AR and INF. In LTX-AR patients were observed a correlation between SAA levels and peripheral CD4+ lymphocyte percentage (r=0.9, p<0.01) and a reverse correlation with FVC percentages (r -0.94, p=0.01). Conclusions: SAA may represent a potential biomarker of LTX acute complications, with a prognostic value in AR. 

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Published
Mar 15, 2020
DOI: https://doi.org/10.36141/svdld.v37i1.8775

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How to Cite

1.
Vietri L, Bargagli E, Bennett D, Fossi A, Cameli P, Bergantini L, et al. Serum amyloid A in lung transplantation. Sarcoidosis Vasc Diffuse Lung Dis [Internet]. 2020 Mar. 15 [cited 2024 Jul. 17];37(1):2-7. Available from: https://mattioli1885journals.com/index.php/sarcoidosis/article/view/8775
Issue
Vol. 37 No. 1 (2020)
Section
Original Articles: Clinical Research

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How to Cite

1.
Vietri L, Bargagli E, Bennett D, Fossi A, Cameli P, Bergantini L, et al. Serum amyloid A in lung transplantation. Sarcoidosis Vasc Diffuse Lung Dis [Internet]. 2020 Mar. 15 [cited 2024 Jul. 17];37(1):2-7. Available from: https://mattioli1885journals.com/index.php/sarcoidosis/article/view/8775
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