Unusual bone localization of sarcoidosis mimicking metastatic lesions

Besma Hamdi; Emna Ben Jemai; Monia Attia; Ikbel Khalfallah; Hend Riahi; Anissa Berraies; Mohamed Faouzi Ladeb; Soumaya Rameh; Agnes Hamzaoui

doi:10.36141/svdld.v39i3.8744

Unusual bone localization of sarcoidosis mimicking metastatic lesions

Authors

Besma Hamdi Pulmonology Departement Diseases, Abderrahmen Mami hospital,Ariana 2080, Tunisia
Emna Ben Jemai Pulmonology Departement Diseases, Abderrahmen Mami hospital,Ariana 2080, Tunisia; University of Tunis El Manar, Faculty of Medicine of Tunis, Tunis 1007, Tunisia,
Monia Attia Medical Imaging Departement, Abderrahmen Mami Hospital, Ariana 2080, Tunisia, University of Tunis El Manar, Faculty of Medicine of Tunis, Tunis 1007, Tunisia,
Ikbel Khalfallah Pulmonology Departement Diseases, Abderrahmen Mami hospital,Ariana 2080, Tunisia. University of Tunis El Manar, Faculty of Medicine of Tunis, Tunis 1007, Tunisia,
Hend Riahi Medical Imaging Departement, Kassab Orthopedic Institute ; Ksar Said, Tunisia
Anissa Berraies Pulmonology Departement Diseases, Abderrahmen Mami hospital,Ariana 2080, Tunisia
Mohamed Faouzi Ladeb Medical Imaging Departement, Kassab Orthopedic Institute ; Ksar Said, Tunisia. University of Tunis El Manar, Faculty of Medicine of Tunis, Tunis 1007, Tunisia
Soumaya Rameh Anatomopathologic departement, Charle Nichole Hospital, Tunisia. University of Tunis El Manar, Faculty of Medicine of Tunis, Tunis 1007, Tunisia
Agnes Hamzaoui Pulmonology Departement Diseases, Abderrahmen Mami hospital,Ariana 2080, Tunisia. University of Tunis El Manar, Faculty of Medicine of Tunis, Tunis 1007, Tunisia,

Keywords:

Sarcoidosis ; Bone lesions ; Radiographic imaging ; Granuloma

Abstract

Sarcoidosis is a multisystem disease of unknown origin. Diagnosis remains challenging, based on organ site involvement, histological confirmation of non-caseating granuloma and an appropriate clinical syndrome. Granulomatous bone involvement is rare and may be ignored because it is usually asymptomatic. Vertebrae, ribs and skull localizations are rarely reported. We described an interesting case of a woman with chronic and multiorgan sarcoidosis with unusual bone localizations.

References

Valeyre D, Prasse A, Nunes H, Uzunhan Y, Brillet P-Y, Müller-Quernheim J. Sarcoidosis. Lancet. 2014 Mar 29;383(9923):1155-67.

Bechman K, Christidis D, Walsh S, Birring SS, Galloway J. A review of the musculoskeletal manifestations of sarcoidosis. Rheumatology (Oxford). 2018 May 1;57(5):777-783.

Wilcox A, Bharadwaj P, Sharma OP. Bone sarcoidosis. Curr Opin Rheumatol. 2000 Jul;12(4):321-30.

Zhou Y, Lower EE, Li H, Farhey Y, Baughman RP. Clinical characteristics of patients with bone sarcoidosis. Semin Arthritis Rheum. 2017 Aug;47(1):143-148.

Hyldgaard C, Bendstrup E, Hilberg O, Hjorthaug K, Løvgreen M. An unusual presentation of sarcoidosis with tetraplegia and severe osteolytic bone lesions. Eur Respir J. 2011 Apr;37(4):964-6.

Valencia MP, Deaver PM, Mammarappallil MC. Sarcoidosis of the thoracic and lumbar vertebrae, mimicking metastasis or multifocal osteomyelitis by MRI: case report. Clin Imaging. 2009 Nov-Dec;33(6):478-81.

Moore SL, Kransdorf MJ, Schweitzer ME, Murphey MD, Babb JS. Can sarcoidosis and metastatic bone lesions be reliably differentiated on routine MRI? AJR Am J Roentgenol. 2012 Jun;198(6):1387-93.

Buteau JP, Asuaje ED, Rousseau É et al. The great mimicker: an extensive bone sarcoidosis. Eur J Nucl Med Mol Imaging. 2015 Feb;42(2):364-5.

Baughman RP, Valeyre D, Korsten P, et al. ERS clinical practice guidelines on treatment of sarcoidosis. Eur Respir J 2021; 58: 2004079

Valeyre D, Jeny F, Rotenberg C et al. How to tackle the diagnosis and treatment in the diverse scenarios of extrapulmonary sarcoidosis. Adv Ther 2021 Sep;38(9):4605-4627. doi: 10.1007/s12325-021

Sakellariou GT, Anastasilakis AD, Karanikolas D, Vounotrypidis P, Berberidis C. Central skeletal sarcoidosis: a case report with sustained remission only on methotrexate, and a literature review on the imaging approach, treatment, and assessment of disease activity. Mod Rheumatol. 2013 Jan;23(1):175-81.

Salmon JH, Perotin JM, Direz G, Brochot P, Laredo JD, Eschard JP. [Vertebral sarcoidosis. Spontaneous favorable outcome: A case report and literature review]. Rev Med Interne. 2013 Jan;34(1):42-6.

Bargagli E, Olivieri C, Penza F et al. Rare localizations of bone sarcoidosis: two case reports and review of the literature. Rheumatol Int. 2011 Nov;31(11):1503-6.

Moore SL, Teirstein A, Golimbu C. MRI of Sarcoidosis Patients with Musculoskeletal Symptoms. AJR Am J Roentgenol. 2005 Jul;185(1):154-9.

Lefere M, Larbi A, Malghem J, Vande Berg B, Dallaudière B. Vertebral sarcoidosis: long-term follow-up with MRI. Skeletal Radiol. 2014 Aug;43(8):1185-90.

Malghem J, Vande BB, Lecouvet F, Koutaissoff S, Maldague B. [Principles of analysis for sacroiliac joints imaging]. JBR-BTR. 2007 Sep-Oct;90(5):358-67. Review. French.