The frequency of diastolic dysfunction in patients with sarcoidosis and it’s relationship with HLA DRB1* alleles

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Ezgi Ozyilmaz
Rabia Akilli
Ilayda Berk
Ali Deniz
Ozlem Goruroglu Ozturk
Oya Baydar
Yasemin Saygideger
Gulsah Seydaoglu
Eren Erken

Keywords

Sarcoidosis, Echocardiography, HLA alleles, Diastolic dysfunction

Abstract

Background: Impaired systolic functions are a frequent clinical scene in sarcoidosis however the frequency of diastolic dysfunction (DD) and it’s possible genetic basis has not been fully elucidated yet. The aim of this study is to evaluate the frequency of LVDD and RVDD and its possible relationship between HLA DRB1* alleles in patients with sarcoidosis.


Methods: Seventy seven patients (mean age, 41.1 ±8.2 and 51 were females) without known sarcoid related or any other structured heart disease and 77 healthy controls with a similar age and gender (38.7 ±7.8 and 51 females) were included for the case control study. RVDD was defined as E/A ratio<1 or >2 on tricuspit valve. LVDD was defined as E/A ratio<1 or >2 on mitral valve, with isovolumetric relatation time >90 miliseconds (msn) or Edec>220msn respectively. All patients were HLA typed with the Sequence Specific Oligonucleotide Probe (SSOP) method.


Results: The frequencies of left and right ventricular DD were significantly higher in sarcoidosis patients than the controls (26.0% vs. 2.6% for LVDD; and 42.9% vs. 18.2% for RVDD)(p<0.05). No significant difference was found in patients according to the presence of right and left ventricular DD in terms of age, gender or respiratory function test parameters.


Although the frequency of HLA DRB1* alleles were comparable among patients with RVDD, HLA DRB1*14 alleles were more frequent in patients with LVDD.


Conclusions: Biventricular DD is common in patients with sarcoidosis without manifest cardiac involvement. HLA DRB1*14 allele seems to be related with LVDD in this study population.

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