Sarcoidosis development during ulcerative colitis remission in a patient with a susceptible human leukocyte antigen genotype
Keywords:
ulcerative colitisAbstract
The combination of sarcoidosis and ulcerative colitis (UC) is very rare, and its pathogenesis remains unknown. Hereditary factors as well as environmental factors have been speculated, including an association between human leucocyte antigen (HLA) genotype. A 62-year-old Japanese woman with UC presented complaining of a cough. Abnormal shadows were evident on chest X-ray during mesalazine therapy. Multiple indolent subcutaneous nodules were also detected. Transbronchial lung and skin biopsies showed non-caseous epithelioid granulomas, which was pathologically compatible with sarcoidosis. After steroid therapy, she became asymptomatic and the abnormal shadows and the subcutaneous nodules disappeared. HLA analysis revealed that she harbored the sarcoidosis-related HLA DR14 allele, as well as UC-related HLA B52 and DR15 alleles. The present case suggested that a susceptible HLA genotype may influence the onset of the combination of sarcoidosis and UC.
Downloads
Published
Issue
Section
License
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Transfer of Copyright and Permission to Reproduce Parts of Published Papers.
Authors retain the copyright for their published work. No formal permission will be required to reproduce parts (tables or illustrations) of published papers, provided the source is quoted appropriately and reproduction has no commercial intent. Reproductions with commercial intent will require written permission and payment of royalties.
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
How to Cite
