Efficacy and safety of infliximab therapy in refractory upper respiratory tract sarcoidosis: experience from the STAT registry

Main Article Content

Thomas Barba
Alicia Marquet
Diane Bouvry
Fleur Cohen-Aubart
Marc Ruivard
Sébastien Debarbieux
Chahéra Khouatra
Alain Vighetto
Audrey de Parisot
Dominique Valeyre
Pascal Sève

Keywords

Refractory sarcoidosis, TNF antagonists, Upper respiratory tract

Abstract

Background: Upper respiratory tract (URT) involvement in sarcoidosis may be refractory to corticosteroids and immunosuppressants. Whether TNF-antagonists are efficient and safe in such phenotype is unknown. Methods: STAT is a French national drug registry including patients presenting sarcoidosis treated with TNF alpha antagonists. All cases of biopsy-proven sinonasal and laryngeal sarcoidosis were extracted and retrospectively analyzed from July 2014 to July 2015. Results: Twelve patients presenting biopsy-proven sarcoidosis with URT involvement were included in the STAT registry. Infliximab appeared effective in decreasing URT symptoms, as assessed by a significant decrease of the e-POST (extra-pulmonary Physician Organ Severity Tool) (1.5 [0-2] vs 5 [1.5-5], p=0.03) and a corticosteroids-sparing effect (7.5mg per day [5-10] vs 17.5 mg per day [7.5-20], p=0.04) at the end of follow-up. Conclusions: TNF-antagonists may be an efficient treatment of refractory URT manifestations and should be discussed when prolonged or high dosages of corticosteroids despite immunosuppressive therapy are required.

Downloads

Download data is not yet available.
Abstract 240 | PDF Downloads 67

Most read articles by the same author(s)

1 2 > >>