Predictive factors for the effect of pirfenidone in idiopathic pulmonary fibrosis

Predictive factors for the effect of pirfenidone in idiopathic pulmonary fibrosis

Authors

  • Yasunori Ichimura Chiba University, Graduate School of Medicine, Department of Respirology
  • Kenji Tsushima Chiba University, Graduate School of Medicine, Department of Respirology
  • Takuma Matsumura Chiba University, Graduate School of Medicine, Department of Respirology
  • Kazutaka Yamagishi Chiba University, Graduate School of Medicine, Department of Respirology
  • Mitsuhiro Abe Chiba University, Graduate School of Medicine, Department of Respirology
  • Jun Ikari Chiba University, Graduate School of Medicine, Department of Respirology
  • Jiro Terada Chiba University, Graduate School of Medicine, Department of Respirology
  • Koichiro Tatsumi Chiba University, Graduate School of Medicine, Department of Respirology

Keywords:

Pirfenidone, Idiopahic pulmonary fibrosis, Chest computed tomography, Sumikawa score, Antinuclear antibodies and autoimmune antibodies

Abstract

Fibrotic interstitial lung diseases (ILDs) include a number of pulmonary disorders characterized by infiltration of inflammatory cells in lung parenchyma and fibrosis resulting in decreased lung compliance. Idiopathic pulmonary fibrosis (IPF) represents the most common ILD. ILDs can be divided in two anatomo-pathological and radiographic patterns: usual interstitial pneumonitis (UIP) and non-specific interstitial pneumonitis (NSIP). The different radiological features of UIP and NSIP are discussed. The American Thoracic Society, the European Respiratory Society, the Japanese Respiratory Society, and the Latin American Thoracic Association guidelines for the diagnosis and management of IPF have identified several characteristic high-resolution computed tomography (HRCT) features of UIP. However, even if these guidelines recommend to avoid surgical lung biopsy in case of confident UIP diagnosis on HRCT, they present some limitations, the most important of which is represented by interobserver agreement. Magnetic resonance imaging (MRI) can be considered as a radiation-free alternative to HRCT for several lung diseases. However, the clinical value of MRI for IPF diagnosis remains to be proven. 

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Published

01-02-2018

Issue

Section

Original Articles: Clinical Research

How to Cite

1.
Ichimura Y, Tsushima K, Matsumura T, Yamagishi K, Abe M, Ikari J, et al. Predictive factors for the effect of pirfenidone in idiopathic pulmonary fibrosis. Sarcoidosis Vasc Diffuse Lung Dis [Internet]. 2018 Feb. 1 [cited 2025 Mar. 10];34(4):290-9. Available from: https://mattioli1885journals.com/index.php/sarcoidosis/article/view/5630