Acute exacerbation of idiopathic interstitial pneumonia after nonpulmonary surgery under general anesthesia: a retrospective study

Acute exacerbation of idiopathic interstitial pneumonia after nonpulmonary surgery under general anesthesia: a retrospective study

Authors

  • Kenta Furuya Toho university Oomori hospital
  • Susumu Sakamoto
  • Yujiro Takai
  • Nobukazu Sato
  • Keiko Matsumoto
  • Sakae Homma

Keywords:

Acute exacerbation, Idiopathic interstitial pneumonia, Risk factors, Propofol

Abstract

Background: Idiopathic interstitial pneumonia (IIP) is associated with increased risk of acute exacerbation after lung surgery, which has a poor prognosis and can be fatal. Although some studies have investigated acute exacerbation of IIP after lung surgery, the incidence and risks of acute exacerbation of IIP after nonpulmonary surgery have not been reported. The aim of present study to evaluate the characteristics and risk factors for acute exacerbation of IIP after nonpulmonary surgery. Methods: We retrospectively reviewed the clinical characteristics of 2908 consecutive patients (1620 men, 1288 women; mean age, 61.7) who underwent nonpulmonary surgery under general anesthesia between April 2008 to April 2013. Using preoperative chest computed tomography images, we identified IIP cases and compared preoperative characteristics, laboratory findings, and anesthesia conditions among patients who did and did not develop AE. Results: We extracted 103 IIP patients who underwent nonpulmonary surgery; postoperative acute exacerbation of IIP developed in 8 (7.8%). Univariate analysis identified several risk factors, namely, emergency surgery, preoperative prednisolone use, high serum C-reactive protein, lactate dehydrogenase, white blood cell count, low serum albumin and propofol use during anesthesia. Conclusion: The results suggest that the incidences of postoperative acute exacerbation of IIP are similar after nonpulmonary and pulmonary surgery. In addition, propofol use during anesthesia is a possible risk factor for acute exacerbation of IIP after nonpulmonary surgery. 


Author Biography

Kenta Furuya, Toho university Oomori hospital

Respiratory medicine, Resident

Downloads

Published

25-08-2017

Issue

Section

Original Articles: Clinical Research

How to Cite

1.
Furuya K, Sakamoto S, Takai Y, Sato N, Matsumoto K, Homma S. Acute exacerbation of idiopathic interstitial pneumonia after nonpulmonary surgery under general anesthesia: a retrospective study. Sarcoidosis Vasc Diffuse Lung Dis [Internet]. 2017 Aug. 25 [cited 2025 Apr. 2];34(2):156-64. Available from: https://mattioli1885journals.com/index.php/sarcoidosis/article/view/5366