Validation of the King’s Sarcoidosis Questionnaire (KSQ) in a Dutch sarcoidosis population

Validation of the King’s Sarcoidosis Questionnaire (KSQ) in a Dutch sarcoidosis population

Authors

  • Mirjam J. G. van Manen ¹Department of Pulmonary Medicine, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.
  • Monique Wapenaar ¹Department of Pulmonary Medicine, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.
  • Bert Strookappe 2Ild care foundation research team, The Netherlands. 3Department of Physical Therapy, Hospital Gelderse Vallei Ede, The Netherlands.
  • Marjolein Drent 2Ild care foundation research team, The Netherlands. 4Department of Pharmacology and Toxicology, Faculty of Health, Medicine and Life Science, Maastricht University, The Netherlands. 5Department of Pulmonology, Center of Interstitial Lung Diseases, St. Antonius Hospital, Nieuwegein, The Netherlands.
  • Marjon Elfferich 2Ild care foundation research team, The Netherlands.
  • Jolanda de Vries 2Ild care foundation research team, The Netherlands. 6Department of Medical Psychology, St. Elisabeth Hospital Tilburg and Department of Medical and Clinical Psychology, Tilburg University, The Netherlands.
  • Harry R. Gosker 7NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center, Department of Respiratory Medicine, Maastricht, The Netherlands.
  • Surinder S. Birring 8Division of Asthma, Allergy and Lung Biology, King's College Hospital, London, UK.
  • Amit S. Patel 8Division of Asthma, Allergy and Lung Biology, King's College Hospital, London, UK.
  • Leon van den Toorn ¹Department of Pulmonary Medicine, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.
  • Bernt van den Blink ¹Department of Pulmonary Medicine, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.
  • Karin Boomars ¹Department of Pulmonary Medicine, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.
  • Elske Hoitsma 9Department of Neurology, Diaconessenhuis, Leiden, The Netherlands.
  • Marlies S. Wijsenbeek ¹Department of Pulmonary Medicine, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.

Keywords:

Sarcoidosis, Health status, Questionnaire, Quality of Life

Abstract

ABSTRACT

Background

The King’s Sarcoidosis Questionnaire (KSQ) is a brief questionnaire assessing health status using five modules (General Health Status, Lung, Eyes, Skin, Medication) in patients with sarcoidosis. The KSQ was only validated in one English sarcoidosis cohort.

Objective

The aim of this study was to validate the KSQ in a Dutch sarcoidosis population.

Methods

The KSQ was translated according to international guidelines and tested in interviews with patients. Consecutive outpatients completed multiple questionnaires twice, two weeks apart. Construct validity, internal consistency and repeatability were determined.

Results

Of the 98 patients included 85 had lung, 22 skin and 24 eye disease. There was good construct validity of the KSQ General Health Status module against the World Health Organization Quality of Life-BREF questionnaire. The Medication module correlated weak to moderate with most questionnaires. The correlations with organ-specific questionnaires varied from strong for Eyes (r=0.75), Skin (r=-0.62) to moderate for Lung (r=-0.45 with MRC breathlessness scale). Internal consistency was good for all KSQ modules (Cronbach’s α 0.72-0.93). Intraclass correlation coefficients (0.70-0.90) and Bland-Altman plots showed good repeatability of the KSQ.

Conclusion

The Dutch KSQ is the first translation of the English KSQ, validated in a Dutch sarcoidosis population.

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Published

29-03-2016

Issue

Vol. 33 No. 1 (2016)

Section

Original Articles: Clinical Research

License

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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How to Cite

1.
van Manen MJG, Wapenaar M, Strookappe B, Drent M, Elfferich M, de Vries J, et al. Validation of the King’s Sarcoidosis Questionnaire (KSQ) in a Dutch sarcoidosis population. Sarcoidosis Vasc Diffuse Lung Dis [Internet]. 2016 Mar. 29 [cited 2025 Mar. 19];33(1):75-82. Available from: https://mattioli1885journals.com/index.php/sarcoidosis/article/view/4665