High-resolution CT predictors of hypersensitivity pneumonitis

High-resolution CT predictors of hypersensitivity pneumonitis

Authors

  • Gilles Rival Centre Hospitalier Régional Universitaire de Besançon
  • Philippe Manzoni Centre Hospitalier Régional Universitaire de Besançon
  • Yves Lacasse Institut universitaire de Cardiologie et de Pneumologie de Québec
  • Jean Charles Polio Centre Hospitalier Régional Universitaire de Besançon
  • Virginie Westeel Centre Hospitalier Régional Universitaire de Besançon
  • André Dubiez Centre Hospitalier Régional Universitaire de Besançon
  • Thibaud Soumagne Centre Hospitalier Régional Universitaire de Besançon
  • François Laurent Université Bordeaux, Centre de Recherche Cardio-Thoracique de Bordeaux
  • Jean Charles Dalphin Centre Hospitalier Régional Universitaire de Besançon

Keywords:

HRCT, hypersensitivity pneumonitis, diagnostic procedures

Abstract

Background: The purpose of this study was to evaluate the use of high-resolution chest computed tomography (HRCT) to distinguish hypersensitivity pneumonitis (HP) from other diffuse parenchymal lung diseases (DPLDs). Methods: We examined 130 consecutive patients admitted to our hospital with DPLDs proved by HRCT. Patients underwent clinical and paraclinical examinations. Two readers interpreted 111 HRCT scans using predefined criteria. Results: The findings in patients with HP were compared to those with other DPLDs (non-HP) by univariate and multivariate analyses. Five independent radiological predictors were identified and were given a weight according to their regression coefficient: ground-glass attenuation nodules (4 points), homogeneous ground-glass opacity (3 points), patchy ground-glass opacity (2 points), absence of adenopathy (2 points), and absence of linear/reticular patterns (2 points). A total score (that we called “diagnostic index”) of 5 offered the best trade-off between sensitivity and specificity. At this point of the ROC curve, the sensitivity, specificity, and likelihood ratio were 74%, 90% and 7.7, respectively. Given a pre-test probability of HP of 34% (i.e., 38 HP / 111 patients), the post-test probability was 79%. Conclusion: Our results provide evidence that HRCT can accurately distinguish HP from other DPLDs.

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Published

01-08-2016

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Section

Original Articles: Clinical Research

How to Cite

1.
Rival G, Manzoni P, Lacasse Y, Polio JC, Westeel V, Dubiez A, et al. High-resolution CT predictors of hypersensitivity pneumonitis. Sarcoidosis Vasc Diffuse Lung Dis [Internet]. 2016 Aug. 1 [cited 2025 Jul. 8];33(2):117-23. Available from: https://mattioli1885journals.com/index.php/sarcoidosis/article/view/4552