Bone mineral density in patients with interstitial lung disease

Bone mineral density in patients with interstitial lung disease

Authors

  • Esam H Alhamad King Saud University
  • Rufai Nadama King Saud University

Keywords:

bone mineral density, interstitial lung disease, idiopathic pulmonary fibrosis, osteoporosis, osteopenia, usual interstitial pneumonia

Abstract

Objective: To determine the prevalence of low bone mineral density (BMD) and the risk factors for osteoporosis in patients with interstitial lung disease (ILD). Methods: Consecutive newly diagnosed ILD patients (n=196) were included in the study. Detailed demographic and clinical data were collected at the time of diagnosis, along with BMD measurements. Univariate and multivariate logistic regression analyses were used to determine the risk factors for osteoporosis. Results: Forty-four percent of the patients had osteoporosis, and 36% had osteopenia. The diagnosis of usual interstitial pneumonia (UIP) was more frequently observed in the patients with osteoporosis than in those without osteoporosis (67 vs. 47%, respectively; p=0.005). The univariate analyses identified the following five variables that were associated with an increased risk of osteoporosis at any site: older age (odds ratios [OR], 1.06; 95% confidence intervals [CI], 1.04 - 1.09; p<0.0001), UIP diagnosis (OR, 2.39; 95% CI, 1.33 - 4.30; p=0.003), higher partial pressure of carbon dioxide (PaCO2) (OR, 1.08; 95% CI, 1.01 - 1.14; p=0.01), hypertension (OR, 1.92; 95% CI, 1.05 - 3.49; p=0.033) and diabetes mellitus (OR, 2.38; 95% CI, 1.25 - 4.56; p=0.008). However, older age was the only independent predictor of osteoporosis (adjusted OR, 1.05; 95% CI, 1.02 to 1.08; p=0.001). Conclusions: We observed a high prevalence of osteoporosis and osteopenia among newly diagnosed ILD patients. Our findings suggest that there is a substantially increased risk of osteoporosis and that early screening and aggressive treatment with various anti-bone resorptive therapies are necessary in ILD patients. (Sarcoidosis Vasc Diffuse Lung Dis 2015; 32: 151-159)

Author Biographies

Esam H Alhamad, King Saud University

Associate professor of Medicine

Pulmonary Division, Department of Medicine

Rufai Nadama, King Saud University

Consultant pulmonary Medicine

Pulmonary Division, Department of Medicine

Downloads

Published

22-07-2015

Issue

Section

Original Articles: Clinical Research

How to Cite

1.
Alhamad EH, Nadama R. Bone mineral density in patients with interstitial lung disease. Sarcoidosis Vasc Diffuse Lung Dis [Internet]. 2015 Jul. 22 [cited 2025 May 20];32(2):151-9. Available from: https://mattioli1885journals.com/index.php/sarcoidosis/article/view/3780