Adalimumab Induced Subcutaneous Nodular Sarcoidosis; A Rare Side Effect of Tumor Necrosis Factor-α Inhibitor

Adalimumab Induced Subcutaneous Nodular Sarcoidosis; A Rare Side Effect of Tumor Necrosis Factor-α Inhibitor

Authors

  • Sonoa Au University of Illinois at Chicago
  • Mehdi Mirsaeidi University of Illinois at Chicago
  • Iris K Aronson University of Illinois at Chicago
  • Nadera J. Sweiss University of Illinois at Chicago

Keywords:

pulmonary sarcoidosis, anti-TNF-α antibody, adalimumab, subcutaneous nodular sarcoidosis

Abstract

Adalimumab and other tumor necrosis factor-α inhibitors have been shown in the recent years to successfully treat sarcoidosis refractory to systemic corticosteroids and other agents.  However, there have been an increasing number of cases of sarcoidosis paradoxically induced by these agents.  It is hypothesized that this is due to the disruption of the fine balance of cytokines involved in granuloma formation. We describe the first case of adalimumab-induced subcutaneous nodular sarcoidosis in a patient with pulmonary sarcoidosis.

Author Biographies

Sonoa Au, University of Illinois at Chicago

Department of Dermatology

Mehdi Mirsaeidi, University of Illinois at Chicago

Division of Pulmonary and Critical Care, University of Illinois at Chicago, Chicago, IL

Iris K Aronson, University of Illinois at Chicago

Department of Dermatology

Nadera J. Sweiss, University of Illinois at Chicago

Institute for Personalized Respiratory Medicine

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Published

20-10-2014

Issue

Vol. 31 No. 3 (2014)

Section

Case Reports

License

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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How to Cite

1.
Au S, Mirsaeidi M, Aronson IK, Sweiss NJ. Adalimumab Induced Subcutaneous Nodular Sarcoidosis; A Rare Side Effect of Tumor Necrosis Factor-α Inhibitor. Sarcoidosis Vasc Diffuse Lung Dis [Internet]. 2014 Oct. 20 [cited 2025 May 21];31(3):249-51. Available from: https://mattioli1885journals.com/index.php/sarcoidosis/article/view/3331