Clinical experience with pirfenidone in five patients with scleroderma-related interstitial lung disease | Sarcoidosis, Vasculitis and Diffuse Lung Diseases

Yukiko Miura

Department of Respiratory Medicine, National Hospital Organization Ibarakihigashi Hospital, Japan; Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School, Japan

Takefumi Saito

Department of Respiratory Medicine, National Hospital Organization Ibarakihigashi Hospital, Japan

Kazutaka Fujita

Department of Respiratory Medicine, National Hospital Organization Ibarakihigashi Hospital, Japan

Toru Tanaka

Department of Respiratory Medicine, National Hospital Organization Ibarakihigashi Hospital, Japan

Yoshiya Tsunoda

Department of Respiratory Medicine, National Hospital Organization Ibarakihigashi Hospital, Japan

Arata Azuma

Department of Respiratory Medicine, National Hospital Organization Ibarakihigashi Hospital, Japan

Takahito Nei

Department of Respiratory Medicine, National Hospital Organization Ibarakihigashi Hospital, Japan

Yohei Yatagai

Department of Respiratory Medicine, National Hospital Organization Ibarakihigashi Hospital, Japan

Shigen Rin

Department of Respiratory Medicine, National Hospital Organization Ibarakihigashi Hospital, Japan

Akimasa Sekine

Department of Respiratory Medicine, National Hospital Organization Ibarakihigashi Hospital, Japan

Kenji Hayashihara

Department of Respiratory Medicine, National Hospital Organization Ibarakihigashi Hospital, Japan

Keywords

Antifibrotic agent, interstitial lung disease, pirfenidone, scleroderma, vital capacity

Abstract

Interstitial lung disease is the most common complication and cause of death among patients with scleroderma. Scleroderma-related interstitial lung disease has usually been treated with cyclophosphamide; however, its effect was evaluated to be modest and long-term administration of this drug is associated with adverse effects. Herein, we report our clinical experience of administering pirfenidone, which is an antifibrotic agent, in five patients with scleroderma-related interstitial lung disease. All patients demonstrated an increase in vital capacity.

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Published

Oct 20, 2014

How to Cite

1.

Miura Y, Saito T, Fujita K, Tanaka T, Tsunoda Y, Azuma A, Nei T, Yatagai Y, Rin S, Sekine A, Hayashihara K. Clinical experience with pirfenidone in five patients with scleroderma-related interstitial lung disease. Sarcoidosis Vasc Diffuse Lung Dis [Internet]. 2014 Oct. 20 [cited 2023 Jun. 10];31(3):235-8. Available from: https://mattioli1885journals.com/index.php/sarcoidosis/article/view/3326

Issue

Vol. 31 No. 3 (2014)

Section

Case Series

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Author Biographies

Yukiko Miura, Department of Respiratory Medicine, National Hospital Organization Ibarakihigashi Hospital, Japan; Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School, Japan

Department of Pulmonary Medicine and Oncology, an assistant professor

Takefumi Saito, Department of Respiratory Medicine, National Hospital Organization Ibarakihigashi Hospital, Japan

Department of Respiratory Medicine, clinical professor

Kazutaka Fujita, Department of Respiratory Medicine, National Hospital Organization Ibarakihigashi Hospital, Japan

Department of Respiratory Medicine, MD

Toru Tanaka, Department of Respiratory Medicine, National Hospital Organization Ibarakihigashi Hospital, Japan

Department of Respiratory Medicine, MD

Yoshiya Tsunoda, Department of Respiratory Medicine, National Hospital Organization Ibarakihigashi Hospital, Japan

Department of Respiratory Medicine, MD

Arata Azuma, Department of Respiratory Medicine, National Hospital Organization Ibarakihigashi Hospital, Japan

Department of Pulmonary Medicine and Oncology, professor

Takahito Nei, Department of Respiratory Medicine, National Hospital Organization Ibarakihigashi Hospital, Japan

Department of Pulmonary Medicine and Oncology, MD

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