A case of hepatosplenic sarcoidosis accompanied by hypercalcemia
Hepatosplenic Sarcoidosis
Keywords:
Sarcoidosis, Extrapulmonary sarcoidosis, Hepatosplenomegaly, HypercalcemiaAbstract
We present a case diagnosed with hepatosplenic sarcoidosis with hypercalcemia. Elevated liver enzymes and hypercalcemia were detected in the patient who was admitted to the hospital with abdominal pain and dyspnea. Abdominal dynamic magnetic resonance imaging (MRI) showed diffuse, multiple, nodular hyperintense lesions on T2 weighted. Multinuclear giant cells and lymphocytic portal inflammation were seen in the patient's liver biopsy, whose angiotensin-converting enzyme level was high, and hepatosplenic sarcoidosis was diagnosed. Shortness of breath, abdominal pain, and calcium level improved with methylprednisolone treatment.
References
Tana C, Donatiello I, Caputo A, et al. Clinical features, histopathology and differential diagnosis of sarcoidosis. Cells. 2021 Dec 26;11(1):59.
Sève P, Pacheco Y, Durupt F, et al. Sarcoidosis: a clinical overview from symptoms to diagnosis. Cells. 2021 Mar 31;10(4):766.
Brugnaro P, Cattelan F, Morelli E, et al. A case of hepatic and bone marrow sarcoidosis with progressive renal failure: diagnostic and therapeutic challenges. Sarcoidosis, Vasculitis and Diffuse Lung Diseases. 2022 Dec 19;39(4):e2022041–e2022041.
Jammal TE, Dhelft F, Pradat P, et al. Diagnostic value of elevated serum angiotensin-converting enzyme and lymphopenia in patients with granulomatous hepatitis. Sarcoidosis Vasc Diffuse Lung Dis. 2023 Sep 13;40(3):e2023031–e2023031.
Sakai T, Maeda M, Takabatake M, et al. MR imaging of hepatosplenic sarcoidosis. Radiat Med. 1995;13(1):39–41.
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Copyright (c) 2023 Füsun Fakılı, Nazan Gülhan Bayram, Evren Uzun

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