Recurrent spontaneous pneumothorax under nintedanib treatment in ınterstitial lung disease associated with systemic sclerosis

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Soner Şenel https://orcid.org/0000-0001-9311-8179
Tuğba kahraman Denizhan https://orcid.org/0000-0001-7007-1160
Melih Kızıltepe https://orcid.org/0000-0001-6100-2024
Emel Oğuz Kökoğlu https://orcid.org/0000-0002-5475-2182
Nuri Tutar https://orcid.org/0000-0003-3097-4896

Keywords

Systemic Sclerosis, Spontaneus pnomotorax, Nintedanib

Abstract

Interstitial lung disease (ILD) is a common complication that can develop during the course of systemic sclerosis (SSc). Nindetanib is an antifibrotic drug approved for the treatment of systemic sclerosis-associated interstitial lung disease. Although there is an insufficient data on the development of pneumothorax, the safety of Nintedanib treatment is also uncertain. We observed recurrent resistant pneumothorax under nintedanib treatment in a patient with systemic sclerosis-associated interstitial lung disease. Nintedanib use may increase the risk of developing refractory pneumothorax. Ssc patients who are started on nintedanib should be followed carefully for pneumothorax.

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