Scar sarcoidosis: Clinical features and prognostic significance
Main Article Content
Keywords
Sarcoidosis, Scar, Scar Sarcoidosis, Skin
Abstract
Background and aim: Only a few series of patients with scar sarcoidosis (SS) have been reported. Our aim was to analyse the clinical features of SS patients and their relationship to the prognosis of sarcoidosis.
Methods: Patients with systemic sarcoidosis with SS diagnosed between 1980-2017 at Bellvitge University Hospital, were enrolled. Their clinical charts were reviewed to collect the following data: age, sex, ethnicity, number of lesions, location of SS, origin of the scar, association with erythema nodosum or other specific cutaneous lesions, radiological stage at diagnosis, chronic systemic sarcoidosis activity.
Results: Forty two of 728 patients with systemic sarcoidosis presented SS (31 females and 11 males, mean age 47.71±13.747 years). SS was present at the onset of systemic sarcoidosis in 35/42 cases (83.33%). Twelve patients had simultaneously erythema nodosum. In 14 patients SS was the only specific cutaneous lesion of sarcoidosis. Foreign bodies were observed in 16 of 26 biopsied SS lesions (61.54%). Radiological stage at diagnosis was 0 for 2 patients, I for 22, II for 13, III for 4, and IV for 1. The activity of systemic sarcoidosis persisted for more than 5 years in 16/42 patients with SS (38.1%) vs. 186/686 patients with systemic sarcoidosis (27.11%), However the differences were not significant (p=0.154).
Conclusions: SS was observed in 5.77% of our patients with systemic sarcoidosis. It is usually present at the onset of the disease and is an useful sign for suspicion of a diagnosis of sarcoidosis, but it carries no prognostic significance.
References
2. Marcoval J, Mañá J, Rubio M. Specific cutaneous lesions in patients with systemic sarcoidosis: relationship to severity and chronicity of disease. Clin Exp Dermatol 2011;36:739-744.
3. Mañá J, Marcoval J, Graells J, Salazar A, Peyrí J, Pujol R. Cutaneous involvement in sarcoidosis. Relationship to systemic disease. Arch Dermatol 1997; 133:882-888.
4. Atci T, Baykal C, Kaya Bingöl Z, Polat Ekinci A, Kiliçaslan Z. Scar sarcoidosis: 11 patients with variable clinical features and invariable pulmonary involvement. Clin Exp Dermatol 2019;44:826-828.
5. Bae KN, Shin K, Kim HS, Ko HC, Kim B, Kim MB. Scar Sarcoidosis: A retrospective investigation into its peculiar clinicopathologic presentation. Ann Dermatol 2022;34:28-33.
6. Neville E, Walker AN, James DG. Prognostic factors predicting the outcome of sarcoidosis: an analysis of 818 patients. Q J Med 1983;52:525-533.
7. Yanardağ H, Pamuk ON, Karayel T. Cutaneous involvement in sarcoidosis: analysis of the features in 170 patients. Respir Med 2003;97:978-982.
8. Mangas C, Fernández-Figueras MT, Fité E, Fernández-Chico N, Sàbat M, Ferrándiz C. Clinical spectrum and histological analysis of 32 cases of specific cutaneous sarcoidosis. J Cutan Pathol 2006; 33:772-777.
9. García-Colmenero L, Sánchez-Schmidt JM, Barranco C, Pujol RM. The natural history of cutaneous sarcoidosis. Clinical spectrum and histological analysis of 40 cases. Int J Dermatol 2019;58:178-184.
10. Veien NK, Stahl D, Brodthagen H. Cutaneous sarcoidosis in Caucasians. J Am Acad Dermatol 1987;16:534-540.
11. Usmani N, Akhtar S, Long E, Phipps A, Walton S. A case of sarcoidosis occurring within an extensive burns scar. J Plast Reconstr Aesthet Surg 2007;60:1256-1259.
12. Kormeili T, Neel V, Moy RL. Cutaneous sarcoidosis at sites of previous laser surgery. Cutis 2004;73:53-55.
13. Kwon SH, Jeong KM, Baek YS, Jeon J. Linear scar sarcoidosis on thin blepharoplasty line mimicking a hypertrophic scar: a case report. SAGE Open Med Case Rep 2018;6:2050313X18803991.
14. Shuja F, Kavoussi SC, Mir MR, Jogi RP, Rosen T. Interferon induced sarcoidosis with cutaneous involvement along lines of venous drainage in a former intravenous drug user. Dermatol Online J 2009;15:4.
15. Lee YB, Lee JI, Park HJ, Cho BK, Oh ST. Interferon-alpha induced sarcoidosis with cutaneous involvement along the lines of venous drainage. Ann Dermatol 2011;23:239-241.
16. Marcoval J, Penín RM, Mañá J. Specific skin lesions of sarcoidosis located at venipuncture points for blood sample collection. Am J Dermatopathol 2018;40:362-366.
17. James DG. Dermatological aspects of sarcoidosis. QJM 1959;28:109-124.
18. Marcoval J, Mañá J, Moreno A, Gallego I, Fortuño Y, Peyrí J. Foreign bodies in granulomatous cutaneous lesions of patients with systemic sarcoidosis. Arch Dermatol 2001; 137:485-486.
19. Kim YC, Triffet MK, Gibson LE. Foreign bodies in sarcoidosis. Am J Dermatopathol 2000; 22:408-412.
20. Callen JP. The presence of foreign bodies does not exclude the diagnosis of sarcoidosis. Arch Dermatol 2001; 137:485-486.
21. Val-Bernal JF, Sanchez-Quevedo MC, Corral J, Campos A. Cutaneous sarcoidosis and foreign bodies. An electron probe roentgenographic microanalytic study. Arch Pathol Lab Med 1995;119:471-474.
22. Walsh NMG, Hanly JG, Tremaine R, Murray S. Cutaneous sarcoidosis and foreign bodies. Am J Dermatopathol 1993;15:203-207.
Article Sidebar
Article Details
How to Cite
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Transfer of Copyright and Permission to Reproduce Parts of Published Papers.
Authors retain the copyright for their published work. No formal permission will be required to reproduce parts (tables or illustrations) of published papers, provided the source is quoted appropriately and reproduction has no commercial intent. Reproductions with commercial intent will require written permission and payment of royalties.
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
How to Cite
