The factors predicting development of serious infections in ANCA-associated vasculitis

The factors predicting development of serious infections in ANCA-associated vasculitis

Authors

  • Emine Uslu Yurteri Department of Rheumatology, Ankara University Faculty of Medicine, Ankara, Turkey
  • Serdar Sezer Department of Rheumatology, Ankara University Faculty of Medicine, Ankara, Turkey
  • Murat Torgutalp Department of Rheumatology, Ankara University Faculty of Medicine, Ankara, Turkey; Department of Gastroenterology, Infectiology and Rheumatology, Charite Universitatsmedizin Berlin Campus Benjamin Franklin, Berlin, Germany
  • Mucteba Enes Yayla Department of Rheumatology, Ankara University Faculty of Medicine, Ankara, Turkey
  • Didem Sahin Eroglu Department of Rheumatology, Ankara University Faculty of Medicine, Ankara, Turkey https://orcid.org/0000-0003-3558-5400
  • Ilyas Ercan Okatan Department of Rheumatology, Ankara University Faculty of Medicine, Ankara, Turkey
  • Ayse Bahar Kelesoglu Dincer Department of Rheumatology, Ankara University Faculty of Medicine, Ankara, Turkey
  • Emine Gozde Aydemir Guloksuz Department of Rheumatology, Ankara University Faculty of Medicine, Ankara, Turkey
  • Mehmet Levent Yuksel Department of Rheumatology, Ankara University Faculty of Medicine, Ankara, Turkey
  • Tahsin Murat Turgay Department of Rheumatology, Ankara University Faculty of Medicine, Ankara, Turkey
  • Askin Ates Department of Rheumatology, Ankara University Faculty of Medicine, Ankara, Turkey
  • Gulay Kinikli Department of Rheumatology, Ankara University Faculty of Medicine, Ankara, Turkey

Keywords:

Infection, ANCA, vasculitis, mortality

Abstract

Background: Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a rare autoimmune disease usually involving small vessels and progressing with necrotizing inflammation. Treatment requires long-term use of immunosuppressive agents to inhibit disease activity. Serious infections (SIs) are a common complication in AAV.

Objective: The aim of this study was to identify the risk factors for serious infections which required hospitalization in patients with AAV.

Methods: In this retrospective cohort study., we included 84 patients admitted to the Ankara University Faculty of Medicine in the last 10 years with a diagnosis of AAV.

Results: In 42 (50%) of 84 patients followed up with the diagnosis of AAV, an infection requiring hospitalization was identified. The patients’ total corticosteroid dose, use of pulse steroids, induction regimen, levels of C-reactive protein (CRP) and the presence of pulmonary and renopulmonary involvement were found to be associated with the frequency of infection (p=0.015, p=0.016, p=0.010, p=0.03, p= 0.026 and p=0.029, respectively). In multivariable analysis, it was found that renopulmonary involvement (p=0.002, HR=4.95, 95% CI= 1.804-13.605), age of over 65 (p=0.049, HR=3.37, 95% CI=1.004-11.369) and high CRP levels (p=0.043, HR=1.006, 95% CI=1.000-1.011) constituted independent predictors of serious infection risk.

Conclusion: The frequency of infection is known to be increased in ANCA-associated vasculitis. Our study showed that renopulmonary involvement, age and elevated CRP levels on admission are independent risk factors of infection.

Author Biographies

Emine Uslu Yurteri, Department of Rheumatology, Ankara University Faculty of Medicine, Ankara, Turkey

 

 

 

 

 

Serdar Sezer, Department of Rheumatology, Ankara University Faculty of Medicine, Ankara, Turkey

 

 

 

 

 

Murat Torgutalp, Department of Rheumatology, Ankara University Faculty of Medicine, Ankara, Turkey; Department of Gastroenterology, Infectiology and Rheumatology, Charite Universitatsmedizin Berlin Campus Benjamin Franklin, Berlin, Germany

 

 

 

Mucteba Enes Yayla, Department of Rheumatology, Ankara University Faculty of Medicine, Ankara, Turkey

 

 

 

Didem Sahin Eroglu, Department of Rheumatology, Ankara University Faculty of Medicine, Ankara, Turkey

 

 

 

Ilyas Ercan Okatan, Department of Rheumatology, Ankara University Faculty of Medicine, Ankara, Turkey

 

 

 

Ayse Bahar Kelesoglu Dincer, Department of Rheumatology, Ankara University Faculty of Medicine, Ankara, Turkey

 

 

 

Emine Gozde Aydemir Guloksuz, Department of Rheumatology, Ankara University Faculty of Medicine, Ankara, Turkey

 

 

 

Mehmet Levent Yuksel, Department of Rheumatology, Ankara University Faculty of Medicine, Ankara, Turkey

 

 

 

Tahsin Murat Turgay, Department of Rheumatology, Ankara University Faculty of Medicine, Ankara, Turkey

 

 

 

Askin Ates, Department of Rheumatology, Ankara University Faculty of Medicine, Ankara, Turkey

 

 

 

Gulay Kinikli, Department of Rheumatology, Ankara University Faculty of Medicine, Ankara, Turkey

 

 

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Published

29-06-2023

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Section

Original Articles: Laboratory Research

How to Cite

1.
Uslu Yurteri E, Sezer S, Torgutalp M, Yayla ME, Sahin Eroglu D, Okatan IE, et al. The factors predicting development of serious infections in ANCA-associated vasculitis . Sarcoidosis Vasc Diffuse Lung Dis [Internet]. 2023 Jun. 29 [cited 2025 Apr. 4];40(2):e2023015. Available from: https://mattioli1885journals.com/index.php/sarcoidosis/article/view/13243