Cardiac sarcoidosis in an adult person with cystic fibrosis: a case report

Cardiac sarcoidosis in an adult person with cystic fibrosis: a case report

Authors

  • Thomas FitzMaurice Liverpool Heart and Chest Hospital NHS Foundation Trust
  • Robert Cooper Liverpool Heart and Chest Hospital NHS Foundation Trust
  • Richard Snowdon Liverpool Heart and Chest Hospital NHS Foundation Trust
  • Monika Arzanauskaite Liverpool Heart and Chest Hospital NHS Foundation Trust
  • Dilip Nazareth Liverpool Heart and Chest Hospital NHS Foundation Trust
  • Martin Walshaw Liverpool Heart and Chest Hospital NHS Foundation Trust

Keywords:

Sarcoidosis, Cystic fibrosis, Cardiac sarcoidosis, Inflammation

Abstract

Cardiac sarcoidosis and cystic fibrosis (CF) are both rare conditions and their co-existence has not previously been noted in adults. For the first time we report a case of isolated cardiac sarcoidosis in a woman with CF, and discuss the possible combined aetiological factors. As the life expectancy of people with CF continues to increase, clinicians should be aware of the emergence of concomitant inflammatory conditions typically diagnosed in adulthood, and the diagnostic challenges this may present.

Author Biographies

Thomas FitzMaurice, Liverpool Heart and Chest Hospital NHS Foundation Trust

Adult CF Unit

Robert Cooper, Liverpool Heart and Chest Hospital NHS Foundation Trust

Department of Cardiology

Richard Snowdon, Liverpool Heart and Chest Hospital NHS Foundation Trust

Department of Cardiology

Monika Arzanauskaite, Liverpool Heart and Chest Hospital NHS Foundation Trust

Department of Radiology

Dilip Nazareth, Liverpool Heart and Chest Hospital NHS Foundation Trust

Adult CF Unit

Martin Walshaw, Liverpool Heart and Chest Hospital NHS Foundation Trust

Adult CF Unit

References

UK Cystic Fibrosis Registry 2019 Annual Data Report [press release]. UK CF Trust, August 2020 2019.

Strachan D. British Lung Foundation: sarcoidosis statistics: British Lung Foundation; 2021 [cited 2021. Available from: https://statistics.blf.org.uk/sarcoidosis.

Birnie DH, Kandolin R, Nery PB, Kupari M. Cardiac manifestations of sarcoidosis: diagnosis and management. European Heart Journal. 2016;38(35):2663-70.

Birnie DH, Sauer WH, Judson MA. Consensus statement on the diagnosis and management of arrhythmias associated with cardiac sarcoidosis. Heart. 2016;102(6):411.

Kim JS, Judson MA, Donnino R, Gold M, Cooper LT, Prystowsky EN, et al. Cardiac sarcoidosis. American Heart Journal. 2009;157(1):9-21.

Okada DR, Bravo PE, Vita T, Agarwal V, Osborne MT, Taqueti VR, et al. Isolated cardiac sarcoidosis: A focused review of an under-recognized entity. Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology. 2018;25(4):1136-46.

Birnie DH, Nery PB, Ha AC, Beanlands RSB. Cardiac Sarcoidosis. Journal of the American College of Cardiology. 2016;68(4):411-21.

Cooper TJ, Day AJ, Weller PH, Geddes DM. Sarcoidosis in two patients with cystic fibrosis: a fortuitous association? Thorax. 1987;42(10):818-20.

Rettinger SD, Trulock EP, Mackay B, Auerbach HS. Sarcoidosis in an adult with cystic fibrosis. Thorax. 1989;44(10):829-30.

Bombieri C, Luisetti M, Belpinati F, Zuliani E, Beretta A, Baccheschi J, et al. Increased frequency of CFTR gene mutations in sarcoidosis: a case/control association study. Eur J Hum Genet. 2000;8(9):717-20.

Labombarda F, Saloux E, Brouard J, Bergot E, Milliez P. Heart involvement in cystic fibrosis – A specific cystic fibrosis – related myocardial changes? Respir Med. 2016;18:31-38.

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Published

31-03-2022

Issue

Section

Case Reports

How to Cite

1.
FitzMaurice T, Cooper R, Snowdon R, Arzanauskaite M, Nazareth D, Walshaw M. Cardiac sarcoidosis in an adult person with cystic fibrosis: a case report. Sarcoidosis Vasc Diffuse Lung Dis [Internet]. 2022 Mar. 31 [cited 2025 Apr. 30];39(1):e2022002. Available from: https://mattioli1885journals.com/index.php/sarcoidosis/article/view/11967