A case of hepatic and bone marrow sarcoidosis with progressive renal failure: diagnostic and therapeutic challenges

Pierluigi Brugnaro; Francesca Cattelan; Erika Morelli; Andrea Petrucci; Alessandro Marocco; Sandro Panese; Pietro Maria Donisi; Giovanni Capitanio; Mauro Tollot

doi:10.36141/svdld.v39i4.11350

A case of hepatic and bone marrow sarcoidosis with progressive renal failure: diagnostic and therapeutic challenges

Authors

Pierluigi Brugnaro a:1:{s:5:"en_US";s:71:"Infectious Diseases Department, O.C. “SS.Giovanni e Paolo”, Venezia";}
Francesca Cattelan Infectious Diseases Department, O.C. “SS.Giovanni e Paolo”, Venezia
Erika Morelli Infectious Diseases Department, O.C. “SS.Giovanni e Paolo”, Venezia
Andrea Petrucci Infectious Diseases Department, O.C. “SS.Giovanni e Paolo”, Venezia
Alessandro Marocco Infectious Diseases Department, O.C. “SS.Giovanni e Paolo”, Venezia
Sandro Panese Infectious Diseases Department, O.C. “SS.Giovanni e Paolo”, Venezia
Pietro Maria Donisi Pathology Service, O.C. “SS.Giovanni e Paolo”, Venezia
Giovanni Capitanio Pathology Service, O.C. “SS.Giovanni e Paolo”, Venezia
Mauro Tollot Pathology Service, O.C. “SS.Giovanni e Paolo”, Venezia

Keywords:

Sarcoidosis; Extra-pulmonary; Granulomatous diseases

Abstract

Sarcoidosis is a systemic granulomatous disease, sometimes characterized by an extrapulmonary localization in 30 – 50% of cases. We describe a 60-year-old Italian man with an unexplained history of fatigue, ascitis and progressive renal function impairment. Diagnosis of hepatic and bone marrow sarcoidosis was established by histology, and fast improvement of renal function was obtained after starting corticosteroid therapy. Atypical presentation and simultaneous involvement of liver, bone marrow and kidneys make diagnosis of extrapulmonary sarcoidosis still a diagnostic challenge. Delayed diagnosis could lead to serious organ damage like a progressive severe kidney failure.

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