Leukocytoclastic vasculitis associated with multifocal sensory neuropathy responsive to intravenous immunoglobulins: a case report.

Elena  Cama; Martina Ferranti; Mario  Cacciavillani; Franco Schiavon; Mara  Felicetti; Chiara Abriani; Mauro Alaibac

doi:10.36141/svdld.v38i3.10883

Leukocytoclastic vasculitis associated with multifocal sensory neuropathy responsive to intravenous immunoglobulins: a case report.

Authors

Elena Cama Unit of Dermatology, Department of Medicine DIMED, University of Padua
Martina Ferranti Unit of Dermatology, Department of Medicine DIMED, University of Padua
Mario Cacciavillani CEMES, EMG Unit, Padua
Franco Schiavon Unit of Rheumatology, Department of Medicine DIMED, University of Padua
Mara Felicetti Unit of Rheumatology, Department of Medicine DIMED, University of Padua
Chiara Abriani Unit of Neurology, Department of Neurosciences, University of Padua,
Mauro Alaibac Unit of Dermatology, Department of Medicine DIMED, University of Padua

Keywords:

Leukocytoclastic vasculitis, Sensory neuropathy, Intravenous immunoglobulins

Abstract

Leukocytoclastic vasculitis (LCV) is a common form of small-vessel vasculitis, which commonly presents as palpable purpura or petechiae, caused by deposition of circulating immune complexes on vessels walls that attracts granulocytes which damage the vascular endothelium and leading to erythrocytes extravasation. The skin is the most commonly involved organ, but also renal, gastrointestinal, pulmonary, cardiovascular and neurological systems may be affected. Skin lesions may be the initial signs of systemic vasculitis. Systemic symptoms may be present, such us fever, myalgia, abdominal pain and arthralgia. The presence of neuropathy/mononeuritis multiplex is expression of severe vasculitic involvement.

Herein, we describe the case of a patient with leucocytoclastic vasculitis associated to sensitive neuropathy, responsive to intravenous immunoglobulins (IGIV) therapy, after the failure of classic systemic treatments.

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