One year of SARS-CoV-2 pandemic: comparison of infection between health care workers and general population before and after vaccination
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Keywords
SARS-CoV-2, COVID-19, RT-PCR, Healthcare workers, Epidemiology, Vaccination
Abstract
Background: The Covid-19 pandemic in Italy has been characterized by three waves of infection during 2020. Vaccination of healthcare workers started in January 2021, earlier than that of other population groups. The main aim of this study is to compare the spread of the pandemic between HCW and the general population focusing on potential effects of the vaccination. Methods:The study consisted of a retrospective analysis of results of RT-PCR tests performed between 6 March 2020 and 4 April 2021 among HCWs from Bologna, Italy, and those of the general population of Emilia Romagna region. We calculated the crude proportion of positive RT-PCR tests over total tests and the crude prevalence of positive test in population; then, we conducted joinpoint analyses using the Joinpoint Regression Program of the National Cancer Institute. Results: The results of the joinpoint analysis show that both φ and ψ ratio indicators have a similar pattern, with a sharp increase during the early phase of the pandemic, and a strong decrease at the end of the first wave around week 15. In both indicators there are no significant changes in the trend after week 25. Pandemic spread among HCWs appeared earlier than in the general population, but it otherwise appeared to have comparable features. A decline in infection was apparent among HCWs after vaccination.
Conclusions: Surveillance of HCWs would inform on the epidemic in the general population. The apparent effectiveness of the anti-SarsCoV2 vaccine will likely occur in the general population.
References
2. Peckham R. COVID-19 and the anti-lessons of history. Lancet 2020;395:850–2
3. Cong Y, Verlhac P, Reggiori F. The interaction between nidovirales and autophagy components. Viruses 2017;9:182
4. Abd El-Aziz TM, Stockand JD. Recent progress and challenges in drug development against COVID-19 coronavirus (SARS-CoV-2) - an update on the status. Infect Genet Evol. 2020;83:104327. doi:10.1016/j.meegid.2020.104327
5. Zhu N, Zhang D, Wang W, et al. China Novel Coronavirus Investigating and Research Team. A Novel Coronavirus from Patients with Pneumonia in China, 2019. N Engl J Med. 2020 Feb 20;382(8):727-733. doi: 10.1056/NEJMoa2001017. Epub 2020 Jan 24. PMID: 31978945; PMCID: PMC7092803
6. Ciotti M, Angeletti S, Minieri M, et al. COVID-19 Outbreak: An Overview. Chemotherapy. 2019;64(5-6):215-223. doi: 10.1159/000507423. Epub 2020 Apr 7. PMID: 32259829; PMCID: PMC7179549
7. World Health Organization. WHO Coronavirus (COVID-19) Dashboard. https://covid19.who.int (last access on 4.27.2021)
8. Covian C, Retamal-Diaz A, Bueno SM, Kalergis AM. Could BCG vaccination induce protective trained immunity for SARS-CoV-2? Front. Immunol. 2020;11: 970
9. Trumello C, Bramanti SM, Ballarotto G, et al. Psychological Adjustment of Healthcare Workers in Italy during the COVID-19 Pandemic: Differences in Stress, Anxiety, Depression, Burnout, Secondary Trauma, and Compassion Satisfaction between Frontline and Non-Frontline Professionals. Int J Environ Res Public Health. 2020 Nov 12;17(22):8358. doi: 10.3390/ijerph17228358. PMID: 33198084; PMCID: PMC7696387
10. Ministero della Salute del Governo Italiano: Monitoraggio Covid-19 numero 50: https://www.salute.gov.it/portale/nuovocoronavirus/dettaglioNotizieNuovoCoronavirus.jsp?lingua=italiano&menu=notizie&p=dalministero&id=5465, last access on 4.27.2021
11. World Health Organization. Risk assessment and management of exposure of health care workers in the context of COVID-19: interim guidance, 19 March 2020. Geneva, Switzerland: World Health Organization, 2020. [https://apps.who.int/iris/handle/10665/331496]
12. Kim HJ, Fay MP, Feuer EJ, Midthune DN. Permutation tests for joinpoint regression with applications to cancer rates. Stat Med 2000;19:335-51 (correction: Stat Med 2001;20:655)
13. Boffetta P, Violante F, Durando P, et al. Working Group on SARS-CoV-2 Infection in Italian Healthcare Workers. Determinants of SARS-CoV-2 infection in Italian healthcare workers: a multicenter study. Sci Rep. 2021 Mar 11;11(1):5788. doi: 10.1038/s41598-021-85215-4. PMID: 33707646; PMCID: PMC7970984
14. Visci G, Lodi V, Bonfiglioli R, et al. Serologic SARS-CoV-2 testing in healthcare workers with positive RT-PCR test or Covid-19 related symptoms. medRxiv 2020.10.25.20219113; doi: https://doi.org/10.1101/2020.10.25.20219113
15. Moghadas SM, Vilches TN, Zhang K, et al. The impact of vaccination on COVID-19 outbreaks in the United States. Clin Infect Dis. 2021 Jan 30:ciab079. doi: 10.1093/cid/ciab079. Epub ahead of print. PMID: 33515252; PMCID: PMC7929033
16. Bouton TC, Lodi S, Turcinovic J, et al. COVID-19 vaccine impact on rates of SARS-CoV-2 cases and post vaccination strain sequences among healthcare workers at an urban academic medical center: a prospective cohort study. medRxiv [Preprint]. 2021 Mar 31:2021.03.30.21254655. doi: 10.1101/2021.03.30.21254655. PMID: 33821283; PMCID: PMC8020984
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