Elotuzumab in multiple myeloma: a single centre experience
Keywords:
Multiple Myeloma, Elotuzumab, TreatmentAbstract
Background and aims of the work: Elotuzumab is a first-in-class immunostimulatory monoclonal antibody approved in Italy in April 2017 for use in combination with lenalidomide and dexamethasone (ELd) for relapsed/refractory multiple myeloma (MM). We present our single Centre experience with ELd in patients with MM, focusing on the determinants driving the choice of the most appropriate second-line treatment. Methods: We performed a retrospective analysis of patients experiencing a first relapse in the Hematology and Bone Marrow Transplant Unit of the Papa Giovanni XXIII hospital in Bergamo, Italy between April and December of 2017. Results: We tended to administer ELd treatment to young and fit patients with non-aggressive relapsed/refractory MM. In general, ELd was well tolerated. We present details of 2 illustrative cases. Conclusions: The immunostimulatory effects and favorable clinical toxicity profile of elotuzumab make it an ideal drug against MM. Ongoing clinical trials will elucidate its most appropriate placement and its best combination partners to improve disease control and, therefore, the duration and quality of life.
Downloads
Published
Issue
Section
License
OPEN ACCESS
All the articles of the European Journal of Oncology and Environmental Health are published with open access under the CC-BY Creative Commons attribution license (the current version is CC-BY, version 4.0 http://creativecommons.org/licenses/by/4.0/). This means that the author(s) retain copyright, but the content is free to download, distribute and adapt for commercial or non-commercial purposes, given appropriate attribution to the original article.
The articles in the previous edition of the Journal (European Journal of Oncology) are made available online with open access under the CC-BY Creative Commons attribution license (the current version is CC-BY, version 4.0 http://creativecommons.org/licenses/by/4.0/).
Upon submission, author(s) grant the Journal the license to publish their original unpublished work within one year, and the non exclusive right to display, store, copy and reuse the content. The CC-BY Creative Commons attribution license enables anyone to use the publication freely, given appropriate attribution to the author(s) and citing the Journal as the original publisher. The CC-BY Creative Commons attribution license does not apply to third-party materials that display a copyright notice to prohibit copying. Unless the third-party content is also subject to a CC-BY Creative Commons attribution license, or an equally permissive license, the author(s) must comply with any third-party copyright notices.