Neutrophil to lymphocyte ratio and muscular invasion in early-stage bladder cancer: a meta-analysis.
Main Article Content
Keywords
cancer, bladder, urtothelial, muscle invasion, NLR
Abstract
Background: Bladder cancer is the ninth most common cancer worldwide. In its early stages, invasion of the muscle layer of the bladder is the major determinant for cystectomy. The aim of this meta-analysis was to evaluate the potential role of the neutrophil to lymphocyte ratio (NLR) in predicting muscular invasion in early-stage bladder cancer. Methods: A systematic literature search was conducted in Medline, Pubmed, Scopus and Clinicaltrials.gov databases for English language articles published in the last decade. Results: Five studies fulfilling the eligibility criteria were identified (1,612 participants, 1,217 with NMIBC and 395 with MIBC). Pooled results showed that NLR values were significantly higher in patients with MIBC (SMD: 0.45, 95% CI: 0.18-0.73; p=0.001). Conclusions: NLR is significantly higher in patients with MIBC in comparison to those with NMIBC. This simple, widely available and relatively inexpensive parameter might be useful for risk stratification in patients with early-stage BC.
Article Sidebar
Article Details
How to Cite
OPEN ACCESS
All the articles of the European Journal of Oncology and Environmental Health are published with open access under the CC-BY Creative Commons attribution license (the current version is CC-BY, version 4.0 http://creativecommons.org/licenses/by/4.0/). This means that the author(s) retain copyright, but the content is free to download, distribute and adapt for commercial or non-commercial purposes, given appropriate attribution to the original article.
The articles in the previous edition of the Journal (European Journal of Oncology) are made available online with open access under the CC-BY Creative Commons attribution license (the current version is CC-BY, version 4.0 http://creativecommons.org/licenses/by/4.0/).
Upon submission, author(s) grant the Journal the license to publish their original unpublished work within one year, and the non exclusive right to display, store, copy and reuse the content. The CC-BY Creative Commons attribution license enables anyone to use the publication freely, given appropriate attribution to the author(s) and citing the Journal as the original publisher. The CC-BY Creative Commons attribution license does not apply to third-party materials that display a copyright notice to prohibit copying. Unless the third-party content is also subject to a CC-BY Creative Commons attribution license, or an equally permissive license, the author(s) must comply with any third-party copyright notices.