Retraction: Monotherapy with meropenem versus combination therapy of ceftazidime plus amikacin for empirical treatment of cancer patients with Febrile Neutropenic (FN): systematic review and meta-analysis
Keywords:
Febrile Neutropenic, meropenem, ceftazidime, amikacin, meta-analysisAbstract
THIS ARTICLE HAS BEEN RETRACTED
Background: Combination therapy has traditionally been recommended for cancer patients with Febrile Neutropenia (FN), but the results remain controversial. Objective: To evaluate the safety and effectiveness of the two methods in clinical practice. Methods: We performed a meta-analysis of randomized controlled trials (RCT) to compare monotherapy with meropenem versus combination therapy with ceftazidime plus amikacin for empirical treatment of cancer patients with FN. Data on interventions, participants’ characteristics and the outcomes of therapy, were extracted for statistical analysis. Seven trials fulfilled the inclusion criteria. Results: The treatment with ceftazidime plus amikacin was more effective than meropenem (OR = 1.17; 95% CI 0.94 -1.45; 1471 participants). Likewise, the failure rate of meropenem was higher than ceftazidime plus amikacin (OR = 0.87; 95% CI 0.7 -1.08; 1471 participants). A total of five articles mentioned adverse effects in detail. Drug-related adverse effects afflicted more patients treated with ceftazidime plus amikacin (OR = 1.06; 95% CI 0.83 -1.35; 1336 participants). The common responses were nausea, diarrhea, rash, and increase in SGOT, SGPT and bilirubin. The treatment effects of the two therapy methods were almost parallel in adults (OR = 1.04; 95% CI 0.64 -1.67; 378 participants older than 16). Only trials on adults mentioned adverse effects in this review. The use of monotherapy for FN is associated with higher failure than ceftazidime plus amikacin and should be carefully considered pending further analysis. However empirical use of ceftazidime plus amikacin entails more adverse effects. Conclusions: Ceftazidime plus amikacin should be the first choice, and meropenem may be chosen as a last defense against pathogenic bacteria.
Downloads
Published
Issue
Section
License
OPEN ACCESS
All the articles of the European Journal of Oncology and Environmental Health are published with open access under the CC-BY Creative Commons attribution license (the current version is CC-BY, version 4.0 http://creativecommons.org/licenses/by/4.0/). This means that the author(s) retain copyright, but the content is free to download, distribute and adapt for commercial or non-commercial purposes, given appropriate attribution to the original article.
The articles in the previous edition of the Journal (European Journal of Oncology) are made available online with open access under the CC-BY Creative Commons attribution license (the current version is CC-BY, version 4.0 http://creativecommons.org/licenses/by/4.0/).
Upon submission, author(s) grant the Journal the license to publish their original unpublished work within one year, and the non exclusive right to display, store, copy and reuse the content. The CC-BY Creative Commons attribution license enables anyone to use the publication freely, given appropriate attribution to the author(s) and citing the Journal as the original publisher. The CC-BY Creative Commons attribution license does not apply to third-party materials that display a copyright notice to prohibit copying. Unless the third-party content is also subject to a CC-BY Creative Commons attribution license, or an equally permissive license, the author(s) must comply with any third-party copyright notices.