Development of a satisfaction survey to investigate pre- and post- treatment of the neck using hybrid cooperative complexes of hyaluronans in a cohort of Japanese patients
Main Article Content
Keywords
hybrid cooperative complexes, hyaluronic acid, real-world data, patient-reported outcomes, aesthetic treatment
Abstract
Objective: demand for aesthetic treatments to improve the appearance of the neck are increasing worldwide. This real-word data (RWD) collection assesses the effectiveness of a hyaluronic acid based dermal filler Profhilo®, created using NAHYCO® Hybrid Technology, on neck skin laxity, firmness, tone, and texture in a group of Japanese women.
Methods: patients received two treatments: one at baseline, and the second at Day 30. Photographs of the neck were clinically evaluated at baseline, Day 30, and Day 90, using the IBSA neck skin laxity scale. Before treatment at Day 30, and at the follow-up visit at Day 90, doctors and patients answered three survey questions to assess clinical improvements and patient satisfaction related to skin laxity, firmness, and texture. Patients were also asked to record their pain level using the visual analogue scale after each treatment.
Results: fourteen female patients, with a median age of 58 years (range: 53–75 years) and a baseline mean skin laxity score of 3, demonstrated significant improvements in mean skin laxity across evaluation timepoints (P<0.0001). All patients, except one, had results that were improved or much improved following the clinical survey. Many patient’s answers were the same or better than the clinical evaluation and reported low pain levels following injections.
Conclusion: Profhilo® was an effective treatment for improving neck skin laxity, firmness, tone, and texture in a real-world patient satisfaction survey of Japanese patients of varying ages and baseline skin laxity and wrinkle severity.
References
2. Fabi S, Alexiades M, Chatrath V, et al. Facial Aesthetic Priorities and Concerns: A Physician and Patient Perception Global Survey. Aesthet Surg J. 2022; 42(4):NP218-NP229.
3. Fisher GJ, Kang S, Varani J, et al. Mechanisms of photoaging and chronological skin aging. Arch Dermatol. 2002; 138(11):1462-70.
4. Lin KH, Liao YH, Wei ML, Sun CK. Comparative analysis of intrinsic skin aging between Caucasian and Asian subjects by slide-free in vivo harmonic generation microscopy. J Biophotonics. 2020; 13(4):e201960063.
5. Zargaran D, Zoller F, Zargaran A, Weyrich T, Mosahebi A. Facial skin ageing: Key concepts and overview of processes. Int J Cosmet Sci. 2022; 44(4):414-20.
6. Sparavigna A, Bombelli L, Giori AM, Bellia G. Efficacy and Tolerability of Hybrid Complexes of High- and Low-Molecular-Weight Hyaluronan Intradermal Injections for the Treatment of Skin Roughness and Laxity of the Neck. ScientificWorldJournal. 2022; 2022:4497176.
7. Tsukahara K, Fujimura T, Yoshida Y, et al. Comparison of age-related changes in wrinkling and sagging of the skin in Caucasian females and in Japanese females. J Cosmet Sci. 2004; 55(4):351-71.
8. Vashi NA, de Castro Maymone MB, Kundu RV. Aging Differences in Ethnic Skin. J Clin Aesthet Dermatol. 2016; 9(1):31-8.
9. Chan IL, Cohen S, da Cunha MG, Maluf LC. Characteristics and management of Asian skin. Int J Dermatol. 2019; 58(2):131-43.
10. Satardinova E. Hybrid cooperative complexes of high and low molecular weight hyaluronans for facial skin rejuvenation in the Oriental mongoloid face: a case series. Aesthetic Medicine. 2019; 5(2):14-9.
11. Sparavigna A, Cigni C, Grimolizzi F, Bellia G. Neck and face rejuvenation outcomes with Profhilo®: a comparative analysis between Chinese and Caucasian cohorts. Gazzetta Medica Italiana Archivio per le Scienze Mediche. 2023; 182(10):628-33.
12. Sparavigna A, Lualdi R, Cicerone M, Giori AM, Bellia G. A pilot study testing efficacy and tolerability of hybrid cooperative complexes of hyaluronic acid intradermal injections in Chinese women. Aesthetic Medicine and Plastic Surgery. 2023; 1(1):5-12.
13. Young MB, Lai W, Kononov T, Zahr AS. A Rejuvenating treatment targeting "tech neck" lines and wrinkles in Chinese women: A prospective, open-label, single-center study. J Cosmet Dermatol. 2023; 22(1):226-235.
14. Li Y, Liao M, Zhu Y, et al. Hyaluronic Acid Compound Filling Plus Mesotherapy vs Botulinum Toxin A for the Treatment of Horizontal Neck Lines: A Multicenter, Randomized, Evaluator-Blinded, Prospective Study in Chinese Subjects. Aesthet Surg J. 2022; 42(4):NP230-NP41.
15. Liao Z-F, Yang W, Lin F-C, Wang S-W, Hong W-J, Luo S-K. A Case Study: Comprehensive Approach for Treating Horizontal Neck Wrinkles Using Hyaluronic Acid Injections and Thread-Lifting. Aesthetic Plast Surg. 2023; 47(2):765-71.
16. Rongthong A, Wanitphakdeedecha R, Maiprasert M, et al. Efficacy and safety of hyaluronic acid filler on the treatment of horizontal neck lines. J Cosmet Dermatol. 2023; 22(2):433-8.
17. Tseng F, Yu H. Treatment of Horizontal Neck Wrinkles with Hyaluronic Acid Filler: A Retrospective Case Series. Plast Reconstr Surg Glob Open. 2019; 7(8):e2366.
18. Fagien S, Bertucci V, von Grote E, Mashburn JH. Rheologic and Physicochemical Properties Used to Differentiate Injectable Hyaluronic Acid Filler Products. Plast Reconstr Surg. 2019; 143(4):707e-20e.
19. Humzah D, Molina B, Salti G, Cigni C, Bellia G, Grimolizzi F. Intradermal Injection of Hybrid Complexes of High- and Low-Molecular-Weight Hyaluronan: Where Do We Stand and Where Are We Headed in Regenerative Medicine? Int J Mol Sci. 2024; 25(6):3216.
20. Cassuto D, Bellia G, Schiraldi C. An Overview of Soft Tissue Fillers for Cosmetic Dermatology: From Filling to Regenerative Medicine. Clin Cosmet Investig Dermatol. 2021; 14:1857-66.
21. Sparavigna A, Tenconi B. Efficacy and tolerance of an injectable medical device containing stable hybrid cooperative complexes of high- and low-molecular-weight hyaluronic acid: a monocentric 16 weeks open-label evaluation. Clin Cosmet Investig Dermatol. 2016; 9:297-305.
22. Agolli E, Diffidenti B, Zitti N, et al. Hybrid cooperative complexes of high and low molecular weight hyaluronans (Profhilo®): review of the literature and presentation of the VisionHA project. Esperienze Dermatologiche. 2018; 20(1):5-14.
23. Dang A. Real-World Evidence: A Primer. Pharmaceut Med. 2023; 37(1):25-36.
24. US Food & Drug Administration. Real world evidence. 2022; 2022.
25. Tateo A, Siquier-Dameto G, Artzi O, et al. Development and Validation of IBSA Photographic Scale for the Assessment of Neck Laxity. Clin Cosmet Investig Dermatol. 2021; 14:349-54.
26. Nouveau-Richard S, Yang Z, Mac-Mary S, et al. Skin ageing: a comparison between Chinese and European populations: A pilot study. J Dermatol Sci. 2005; 40(3):187-93.
27. Calderón TA, Bleakley A, Jordan AB, Lazonich D, Glanz K. Correlates of sun protection behaviors in racially and ethnically diverse U.S. adults. Prev Med Rep. 2019; 13:346-53.
28. Choquet H, Yin J, Jorgenson E. Cigarette smoking behaviors and the importance of ethnicity and genetic ancestry. Transl Psychiatry. 2021; 11(1):120.
29. Hsu S. Green tea and the skin. J Am Acad Dermatol. 2005; 52(6):1049-59.
30. Kim HH, Cho S, Lee S, et al. Photoprotective and anti-skin-aging effects of eicosapentaenoic acid in human skin in vivo. J Lipid Res. 2006; 47(5):921-30.
31. Cassuto D, Delledonne M, Zaccaria G, Illiano I, Giori AM, Bellia G. Safety Assessment of High- and Low-Molecular-Weight Hyaluronans (Profhilo®) as Derived from Worldwide Postmarketing Data. Biomed Res Int. 2020; 2020:8159047.
32. Gupta MA, Gilchrest BA. Psychosocial aspects of aging skin. Dermatol Clin. 2005; 23(4):643-8.
33. Ribé N., Forzina A. Amarna personal technique for rejuvenation of the neck area. Esperienze Dermatologiche. 2021; 23(3):56-8.
34. Tateo A, Goltsova E, Kramer E, et al. Assessment of neck lines: development and validation of IBSA photographic scale. Aesthetic Medicine. 2023; 9(4):e2023020.
35. da Prato EB, Cartier H, Margara A, et al. The ethical foundations of patient-centered care in aesthetic medicine. Philos Ethics Humanit Med. 2024; 19(1):1.
Article Sidebar
Article Details
How to Cite
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Transfer of Copyright and Permission to Reproduce Parts of Published Papers.
Authors retain the copyright for their published work. No formal permission will be required to reproduce parts (tables or illustrations) of published papers, provided the source is quoted appropriately and reproduction has no commercial intent. Reproductions with commercial intent will require written permission and payment of royalties.
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
How to Cite
