Nuts and bolts of Exosomes in Aesthetic Medicine Nuts and Bolts of Exosomes

Abstract

Over the past decade, the body of knowledge about the behavior and properties of exosomes has grown exponentially, resulting in an overwhelming number of published scientific articles. Exosomes are constitutively synthesized and released by many human cells, plants, animal cells, and even bacteria. Exosomes can be derived from the patient's tissues (autologous exosomes), from other human tissues (allogenic exosomes), and plants, animals, or bacteria (xenogenic exosomes). Exosomes offer innovative treatment options in medical aesthetics, such as repairing, regenerating, and rejuvenating skin tissue, preventing and reducing scarring, regulating pigmentation, promoting hair growth, and increasing the survival of fat grafts in aesthetic treatments. However, the significant cost of production is a clear indication of the industry’s first steps in its development. Furthermore, performing these therapies in a private medical office is expensive, and the technical requirements need an in-depth analysis. The key points identified as corrupting, misleading, or confusing concepts (source, cargo, process of origin, and quantity) should be clarified. For all the above, more clinical trials need to be conducted for regulatory approval because, to our knowledge, no exosome-based products or therapies have been approved by any regulatory agency. Nonetheless, exosome treatments undoubtedly represent a breakthrough for aesthetic regenerative medicine.